(4-chlorophenoxy)acetic acid |
![]() Last updated: 12/01/2021 |
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(Also known as: (4-chlorophenoxy)acetic acid ; PCPA; 4-CPA; 4-ChFu; 4-CPA) |
SUMMARY |
4-CPA is a plant growth regulator that does not have approval for use in the EU. It is highly soluble in water and is quite volatile. Little is known about its persistence in soil and aquatic systems. It is moderately toxic to mammals and has a high potential for bioaccumulation. It is also a recognised irritant. It is moderately toxic to birds, honeybees and most aquatic organisms. However, it has a relatively low toxicity to fish. |
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A plant growth regulator used fruit setting and thining | |
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Growth - in terms of thinging and fruit set | |
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Tomatoes; Grapes | |
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Current | |
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Current |
UK regulatory status |
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Not approved | ||
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Expired | ||
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Not applicable |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Expired | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Also used in |
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Chemical structure |
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None | |
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C₈H₇ClO₃ | |
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C1=CC(=CC=C1OCC(=O)O)Cl | |
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No data | |
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SODPIMGUZLOIPE-UHFFFAOYSA-N | |
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InChI=1S/C8H7ClO3/c9-6-1-3-7(4-2-6)12-5-8(10)11/h1-4H,5H2,(H,10,11) | |
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Yes |
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Common Name | Relationship | Link |
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(4-chlorophenoxy)acetic acid | - | ![]() |
General status |
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Plant growth regulator, Herbicide | |
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Auxin | |
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Synthetic | |
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Auxin-transport inhibitor. Absorbed by tissue and translocated to roots | |
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122-88-3 | |
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204-581-3 | |
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291 | |
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019401 | |
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26229 | |
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186.59 | |
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(4-chlorophenoxy)acetic acid | |
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4-chlorophenoxyacetic acid | |
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(4-chlorophenoxy)acetic acid | |
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Not known | |
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Not known | |
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Not applicable | |
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Not applicable | |
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Off-white crystalline solid |
Formulations |
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Available in a range of formulations including aerosols, liquids and tablets |
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957 | CA3 CA = Medical and toxicological databases and information systems e.g. TOXNET (click here ) 3 = Unverified data of known source |
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157 | CA3 CA = Medical and toxicological databases and information systems e.g. TOXNET (click here ) 3 = Unverified data of known source |
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Decomposes before boiling | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) 3 = Unverified data of known source |
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Not expected to self ignite; Not highly flammable | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) 3 = Unverified data of known source |
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1.78 X 1002 | Calculated | - | |||||||
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2.25 | CA3 CA = Medical and toxicological databases and information systems e.g. TOXNET (click here ) 3 = Unverified data of known source |
Low | ||||||||
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1.52 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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3.01 | DW4 DW = Don Wauchope personal database for Pka data: Wauchope, R. D. and Edwards, J. Dissociation constants for pesticide active ingredients: a database and comparison with predicted values. MS in preparation 4 = Verified data |
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Weak acid | |||||||||||
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2.40 X 10-02 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Low volatility | ||||||||
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6.48 X 10-08 | CA3 CA = Medical and toxicological databases and information systems e.g. TOXNET (click here ) 3 = Unverified data of known source |
Non-volatile | ||||||||
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Degradation |
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Soil adsorption and mobility |
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- | CA2 CA = Medical and toxicological databases and information systems e.g. TOXNET (click here ) 2 = Unverified data of unknown source |
Mobile | |||||||
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Estimated | ||||||||||
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Fate indices |
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Cannot be calculated | - | - | |||||||||||||||||||||||||
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Other known metabolites |
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centrophenoxine | - | Plant | - | - |
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Low risk | Q3 Q = Miscellaneous internet resources Based on LogP < 33 = Unverified data of known source |
Low risk | |||||||
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850 | C4 C = AGRITOX (click here ) Rat4 = Verified data |
Moderate | ||||||||
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> 180 | CA3 CA = Medical and toxicological databases and information systems e.g. TOXNET (click here ) Lepomis macrochirus3 = Unverified data of known source |
Low | ||||||||
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> 40 | Q2 Q = Miscellaneous internet resources Daphnia magna2 = Unverified data of unknown source |
Moderate | ||||||||
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1.4 | Q2 Q = Miscellaneous internet resources Unknown species2 = Unverified data of unknown source |
Moderate | ||||||||
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1 | A2 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Unknown species2 = Unverified data of unknown source |
Moderate | ||||||||
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> 100 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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General |
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High (class III) | - | - | ||||||||
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850 | C4 C = AGRITOX (click here ) Rat4 = Verified data |
Moderate | ||||||||
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2200 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
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10.6 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
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Exposure from air or water very low as it is usually used inside Small risk of dietary exposure Source: US EPA |
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Low risk of exposure during handling Source: US EPA |
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Health issues |
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Potential irritant Potential kidney toxicant |
Handling issues |
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IMDG Transport Code is usually 8 | |||
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Health: H302 | |||
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Xn - Harmful: R22 | |||
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S2 | |||
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II (Moderately hazardous) | |||
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Usually 3265 | |||
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Packaging Group III (minor danger) |
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(4-chlorophenoxy)acetic acid | ||
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acide 4 chlorophenoxyacetique | ||
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4-CPA | ||
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4-CPA | ||
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4-CPA (acido 4-clorofenossiacetico =PCPA) | ||
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4-CPA | ||
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4-CPA | ||
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4-CPA | ||
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Record last updated: | 12/01/2021 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |