Bifenazate |
![]() Last updated: 12/01/2021 |
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(Also known as: D 2341; HSDB 7002) |
SUMMARY |
Bifenazate is an insecticide approved for use in the EU. It has a low water solubility, volatile and would not be expected to leach to groundwater. Bifenate is also not expected to persist in soil or water systems. It is highly toxic to mammals and a recognised skin, eye and respiratory system irritant. It is moderately toxic to most aquatic organisms, honeybees and earthworms. |
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An effective, new pesticide for phytophagous mite control | |
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Spider mites; Pecan leaf mites; Pacific spider mites; European red mites; Brown almond mite; Six-spotted spider mite | |
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Greenhouse crops; Nursery crops; Landscaped areas; Hops; Avocado; Curcubits; Apples & pears; Quince; Egg plants; Cucumbers; Water melon; Strawberries; Tomatoes | |
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Current | |
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1996, first introduced; 1999, registered USA; 2000, registered UK |
UK regulatory status |
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Approved (RAR active) | ||
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31/07/2024 | ||
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None |
EC Regulation 1107/2009 (repealing 91/414) |
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Approved (RAR active) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Sweden/Italy | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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31/07/2021 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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No | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Also used in |
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Australia, USA |
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Chemical structure |
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None | |
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C₁₇H₂₀N₂O₃ | |
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CC(C)OC(=O)NNC1=C(C=CC(=C1)C2=CC=CC=C2)OC | |
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No data | |
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VHLKTXFWDRXILV-UHFFFAOYSA-N | |
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InChI=1S/C17H20N2O3/c1-12(2)22-17(20)19-18-15-11-14(9-10-16(15)21-3)13-7-5-4-6-8-13/h4-12,18H,1-3H3,(H,19,20) | |
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Yes |
General status |
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Insecticide, Acaricide | |
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Hydrazine carboxylate | |
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950 g kg⁻¹ | |
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EU dossier - Toluene 0.7 g kg⁻¹ | |
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Synthetic | |
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Neuronal inhibitor, non-systemic having contact and residual action. Mitochondrial complex III electron transport inhibitor | |
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149877-41-8 | |
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442-820-5 | |
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736 | |
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000586 | |
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176879 | |
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300.35 | |
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propan-2-yl 2-(4-methoxy[1,1'-biphenyl]-3-yl)hydrazinecarboxylate | |
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isopropyl 3-(4-methoxybiphenyl-3-yl)carbazate | |
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1-methylethyl 2-(4-methoxy[1,1'-biphenyl]-3-yl)hydrazinecarboxylate | |
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- | |
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- | |
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Not applicable | |
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Not applicable | |
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20D | |
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Not applicable | |
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Tetranychus urticae | |
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White to beige coloured crystalline solid as technical material, white as the pure substance |
Formulations |
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Often supplied as a suspension concentrated which is mixed with water and applied as a spray |
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2.06 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low | ||||||||
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210700 | C4 C = AGRITOX (click here ) Acetone4 = Verified data |
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102000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Ethyl acetate5 = Verified data used for regulatory purposes |
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44700 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Methanol5 = Verified data used for regulatory purposes |
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24700 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Toluene5 = Verified data used for regulatory purposes |
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122 | P4 P = Other governments and regulators 4 = Verified data |
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Decomposes before boiling | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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240 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Not expected to self-ignite; Not highly flammable | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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2.51 X 1003 | Calculated | - | |||||||
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3.4 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
High | ||||||||
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1.31 | P4 P = Other governments and regulators 4 = Verified data |
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12.94 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Strong base | |||||||||||
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1.33 X 10-02 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low volatility | ||||||||
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1.01 X 10-03 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-volatile | ||||||||
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Neutral solution: 206nm = 272686, 232nm = 25058, 264nm = 12413, 290nm = 6186 shoulder | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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61.6 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Degradation |
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0.69 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-persistent | |||||||
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0.69 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-persistent | ||||||||
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4.8 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 3 = Unverified data of known source |
Non-persistent | ||||||||
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1 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-persistent | ||||||||
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EU dossier (RAR 2016) lab studies DT₅₀ range <1 - 6.0 days, DT₉₀ range 0.3-12.3 days n=4 | ||||||||||
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1.2 | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
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Tea shoots, n=1 | ||||||||||
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0.85 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Fast | |||||||
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0.51 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-persistent | |||||||
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pH sensitive: DT₅₀ 8.2 days at pH 4, 4.8 days at pH 5, 0.51 days at pH 7 and 0.04 days at pH 9 all at 25 °C | ||||||||||
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0.045 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Fast | ||||||||
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0.45 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Fast |
Soil adsorption and mobility |
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- | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
Slightly mobile | |||||||
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1778 | ||||||||||
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7.0 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Moderately mobile | |||||||
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368 | ||||||||||
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1.16 | ||||||||||
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EU dossier (2016 RAR) Kf range 4.4-14.6 mL g⁻¹, Kfoc range 243-628 mL g⁻¹, 1/n range 1.00-1.24, Soils=4 | ||||||||||
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None |
Fate indices |
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0.98 | Calculated | Low leachability | ||||||||||||||||||||||||||
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3.61 X 10-03 | Calculated | - | |||||||||||||||||||||||||
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Low | Calculated | - | ||||||||||||||||||||||||||
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Slightly mobile | Calculated | - |
Key metabolites |
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Soil | 0.855 | Major fraction, Relevant | |||||
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Soil | 0.333 | Major fraction, Relevant |
Other known metabolites |
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Ref: D-9963 | - | Water (Photolysis) | - | - | |||||
4-hydroxybiphenyl | - | Rat | - | - | |||||
4,4-biphenyl | - | Rat | - | - | |||||
3,4-dihydroxy-[1,1'-biphenyl] (Ref: D-9472) | - | Water (Photolysis) | - | - |
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83 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
Low potential | |||||||
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Not available | - | |||||||||
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> 5000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Low | ||||||||
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> 0.9 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Dog5 = Verified data used for regulatory purposes |
High | |||||||
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> 40 | - | |||||||||
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> 200 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat Reproductive NOAEL5 = Verified data used for regulatory purposes |
Low | ||||||||
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1036 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Colinus virginianus5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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686 mg kg feed⁻¹ | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Anas platyrhynchos5 = Verified data used for regulatory purposes |
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2.1 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Anas platyrhynchos NOEL5 = Verified data used for regulatory purposes |
High | ||||||||
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0.58 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Lepomis macrochirus5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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0.017 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Oncorhynchus mykiss5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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0.5 | J4 J = Pesticide Action Network database (click here ) Daphnia magna4 = Verified data |
Moderate | ||||||||
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0.15 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Daphnia magna5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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0.058 | P4 P = Other governments and regulators Americamysis bahia4 = Verified data |
High | ||||||||
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0.3 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Skeletonema costatum5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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8.50 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Apis mellifera5 = Verified data used for regulatory purposes |
Moderate | |||||||
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> 100 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Apis mellifera5 = Verified data used for regulatory purposes |
Low | ||||||||
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9.6 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Bombus terrestris as mg l⁻¹3 = Unverified data of known source |
Moderate | ||||||||
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> 429 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Eisenia foetida5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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Moderately harmful | Q2 Q = Miscellaneous internet resources Parasitoids2 = Unverified data of unknown source |
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General |
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High (class III) | - | - | ||||||||
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> 5000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Low | ||||||||
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2000 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
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> 4.4 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat 4 hr (nose only)3 = Unverified data of known source |
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0.01 | F5 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) JMPR 20065 = Verified data used for regulatory purposes |
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Not allocated | F5 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) JMPR 20065 = Verified data used for regulatory purposes |
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0.0036 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat 90 day SF=1005 = Verified data used for regulatory purposes |
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1-2 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) concentration dependent5 = Verified data used for regulatory purposes |
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Occupational exposure may occur through inhalation of dust and dermal contact | ||||||||||
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Health issues |
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Harmful if ingested |
Handling issues |
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Not explosive or oxidising IMDG Transport Code is usually 9 |
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Health: H317. H319, H373 Environment: H400, H410 |
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Xn - Harmful: R43 Xi - Irritant: R36 |
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S26, S36/37 | |||
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U (Unlikely to present an acute hazard) | |||
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Usually 3082 | |||
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Packaging Group III (minor danger) |
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bifenazate | ||
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bifenazate | ||
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Bifenazat | ||
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bifenazat | ||
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bifenazate | ||
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bifenazato | ||
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bifenazat | ||
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bifenazat | ||
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Record last updated: | 12/01/2021 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |