| brodifacoum (Ref: WBA 8119) |
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GENERAL INFORMATION 
for brodifacoum
Description: A coumarin rodenticide used inside buildings
Example pests controlled: Rats; Mice; Gophers
Example applications: House; Commercial properties; Industrial sites
Availability status: Current
Introduction & key dates: 1978
EC Regulation 1107/2009 (repealing 91/414):
| Status | Not approved |
| Dossier rapporteur/co-rapporteur | - |
| Date inclusion expires | Expired |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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Also used in: Australia, USA
General status:
| Pesticide type | Rodenticide | |||
| Substance group | Hydrocoumarin | |||
| Minimum active substance purity | >95% | |||
| Known relevant impurities | - | |||
| Substance origin | Synthetic | |||
| Mode of action | 2nd generation anticoagulant | |||
| CAS RN | 56073-10-0 | |||
| EC number | 259-980-5 | |||
| CIPAC number | 370 | |||
| US EPA chemical code | 112701 | |||
| Chiral molecule | Chiral, a specific isomer or a derivative of a chiral molecule | |||
| Chemical formula | C31H23BrO3 | |||
| SMILES | C1C(CC2=CC=CC=C2C1C3=C(OC4=CC=CC=C4C3=O)O)C5=CC=C(C=C5)C6=CC=C(C=C6)Br | |||
| International Chemical Identifier key (InChIKey) | VEUZZDOCACZPRY-UHFFFAOYSA-N | |||
| International Chemical Identifier (InChI) | InChI=1S/C31H23BrO3/c32-24-15-13-20(14-16-24)19-9-11-21(12-10-19)23-17-22-5-1-2-6-25(22)27(18-23)29-30(33)26-7-3-4-8-28(26)35-31(29)34/h1-16,23,27,33H,17-18H2 | |||
| Structure diagram/image available? | Yes | |||
| Molecular mass (g mol-1) | 523.4 | |||
| PIN (Preferred Identification Name) | 3-[(1E,3E)-3-(4'-bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]-4-hydroxy-2H-1-benzopyran-2-one | |||
| IUPAC name | 3-[(1RS,3RS;1RS,3SR)-3-(4'-bromobiphenyl-4-yl)-1,2,3,4-tetrahydro-1-naphthyl]-4-hydroxycoumarin | |||
| CAS name | 3-[3-(4'-bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl]-4-hydroxy-2H-1-benzopyran-2-one | |||
| Other status information | Severe Marine Pollutant | |||
| Herbicide Resistance Classification (HRAC) | Not applicable | |||
| Herbicide Resistance Classification (WSSA) | Not applicable | |||
| Insecticide Resistance Classification (IRAC) | Not applicable | |||
| Fungicide Resistance Classification (FRAC) | Not applicable | |||
| Examples of recorded resistance | - | |||
| Physical state | White fine powder | |||
| Related substances & organisms | - | |||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active now or historically |
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| Example products using this active |
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| UK LERAP status | None | |||
| Formulation and application details | Usually supplied in ready-to-use bait formulations such as granules and pellets or in self-contained control devices. | |||
ENVIRONMENTAL FATE
for brodifacoum
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 0.0038 | P4 | Low | |
| Solubility - In organic solvents at 20oC (mg l-1) | 6000 | C4 - Ethyl acetate | - | |
| 6000 | C4 - Acetone | - | ||
| 6000 | C4 - Benzene | - | ||
| 30000 | C4 - Chloroform | - | ||
| Melting point (oC) | 230 | L3 | - | |
| Boiling point (oC) | Decomposes before boiling | L3 | - | |
| Degradation point (oC) | 50 | L3 | - | |
| Flashpoint (oC) | Not expected to self ignite; Not highly flammable | P4 | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 1.32 X 1006 | Calculated | - |
| Log P | 6.12 | P4 | High | |
| Bulk density (g ml-1)/Specific gravity | 1.42 | L3 | - | |
| Dissociation constant (pKa) at 25oC | Not applicable | L3 | - | |
| Note: Very weak acid | ||||
| Vapour pressure at 25oC (mPa) | 0.13 | C4 | Low volatility | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 2.18 X 10-03 | P4 | Non-volatile | |
| Henry's law constant at 20oC (dimensionless) | 7.35 X 10-03 | Calculated | Volatile | |
GUS leaching potential index  |
0.07 | Calculated | Low leachability | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | 5.67 X 10-03 | Calculated | - |
| Note | - | |||
| Potential for particle bound transport index |
- | Calculated | High | |
| Maximum UV-vis absorption L mol-1 cm-1 | - | - | - | |
| Surface tension (mN m-1) | - | - | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Soil degradation (days) (aerobic) | DT50 (typical) | 84 | L3 | Moderately persistent |
| DT50 (lab at 20oC) | - | - | - | |
| DT50 (field) | 157 | F3 | Persistent | |
| DT90 (lab at 20oC) | - | - | - | |
| DT90 (field) | - | - | - | |
| Note | Best available data | |||
| Plant matrix DT50 (days) | Value | - | - | - |
| Note | - | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | - | - | - |
| Note | - | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | 30 | C4 | Moderately persistent |
| Note | - | |||
| Water-sediment DT50 (days) | - | - | - | |
| Water phase only DT50 (days) | - | - | - | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | P4 | Non-mobile |
| Koc | 9155 | |||
| Notes and range | JRC data: Koc varies with pH 17.8 mL/g @ Ph 8.5, 426579 mL/g @ ph 3.3 and 9155 @ pH 7.3. Other data source: Koc 800 mL/g (US3) | |||
| Freundlich | Kf | - | - | - |
| Kfoc | - | |||
| 1/n | - | |||
| Notes and range | - | |||
| pH sensitivity | - | |||
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF (l kg-1) | 6000 | E2 High risk | High potential |
| CT50 (days) | Not available | - | ||
| Mammals - Acute oral LD50 (mg kg-1) | 0.4 | L3 Rat | High | |
| Mammals - Short term dietary NOEL | (mg kg-1) | - | L3 Rat | - |
| (ppm diet) | 0.02 | - | ||
| Birds - Acute LD50 (mg kg-1) | > 0.31 | L3 Anas platyrhynchos | High | |
| Birds - Short term dietary (LC50/LD50) | - | - | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | 0.051 | L3 Oncorhynchus mykiss | High | |
| Fish - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | 0.98 | J4 Daphnia magna | Moderate | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | - | - | - | |
| Non-target plants | - | - | - | |
| - | - | - | ||
| Algae - Acute 72 hour EC50, growth (mg l-1) | - | - | - | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | - | - | - | |
| Honeybees | Contact acute 48 hour LD50 (μg bee-1) | - | - | - |
| Oral acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Unknown mode acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Earthworms - Acute 14 day LC50 (mg kg-1) | > 994 | P4 Eisenia foetida | Moderate | |
| Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms - e.g. Collembola | LR50 / EC50 / NOEC / % Effect | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Other arthropod (2) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Soil micro-organisms | - | - | - | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for brodifacoum
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Threshold of Toxicological Concern (Cramer Class) |
High (class III) | - | - | |
| Mammals - Acute oral LD50 (mg kg-1) | 0.4 | L3 Rat | High | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | 0.3 | F4 Rabbit | - | |
| Mammals - Inhalation LC50 (mg l-1) | 0.004 | L3 Rat | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | - | - | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | - | - | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | - | - | - | |
| Dermal penetration studies (%) | - | - | - | |
| Dangerous Substances Directive 76/464 | - | - | - | |
| Exposure Limits | - | - | - | |
| Exposure Routes | Public | Low risk due to low concentrations used in baits | ||
| Occupational | Demal absorption may occur | |||
| European MRLs | Click here for the EU MRL pesticide database | |||
| Drinking Water MAC (μg l-1) | - | - | - | |
Health issues:
| Carcinogen | Mutagen | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
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| Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
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| General human health issues | Highly toxic Indirect anticoagulant - severe poisonings may lead to massive haemorrhaging |
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: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found
Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
Not explosive or oxidising | |||
| CLP classification 2013 | - | |||
| EC Risk Classification |
T+ - Very toxic: R26/27/28 T - Toxic: R48/24/25 Xn - Harmful: R43 N - Dangerous for the environment: R50, R53 |
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| EC Safety Classification |
S1/2, S45, S61, S36/37, S60 | |||
| WHO Classification | Ia | - | Extremely hazardous | |
| US EPA Classification (formulation) | I | - | Danger - Highly toxic | |
| UN Number | 3027 | |||
| Waste disposal & packaging |
- | |||
| Language | Name |
| English | brodifacoum |
| French | brodifacoum |
| German | Brodifacoum |
| Danish | brodifacoum |
| Italian | brodifacoum |
| Spanish | brodifacum |
| Greek | - |
| Slovenian | brodifakum |
| Polish | brodifakum |
| Swedish | brodifakum |
| Hungarian | - |
| Dutch | brodifacoum |
Record last updated: Monday 07 December 2015
Contact: aeru@herts.ac.uk