Bromadiolone (Ref: LM 637) |
![]() Last updated: 12/01/2021 |
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(Also known as: broprodifacoum; bromodiolone) |
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An anti-coagulant coumarin-derivative rodenticide mainly used for indoor applications | |
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Rats; Mice | |
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Houses; Commercial buildings; Industrial sites | |
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Current | |
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1976, first reported |
UK regulatory status |
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Not approved | ||
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Not applicable | ||
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Approved | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Italy/Romania | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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31/05/2021 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Yes - low ADI / ARfD / AOEL | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Also used in |
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Australia, USA |
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Chemical structure |
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A chiral molecule which is a mixture of the two isomeric diastereomers (1RS,3RS) and (1RS,3SR) both of which are toxicologically active | |
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C₃₀H₂₃BrO₄ | |
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C1=CC=C(C=C1)C(CC(C2=CC=C(C=C2)C3=CC=C(C=C3)Br)O)C4=C(C5=CC=CC=C5OC4=O)O | |
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No data | |
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OWNRRUFOJXFKCU-UHFFFAOYSA-N | |
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InChI=1S/C30H23BrO4/c31-23-16-14-20(15-17-23)19-10-12-22(13-11-19)26(32)18-25(21-6-2-1-3-7-21)28-29(33)24-8-4-5-9-27(24)35-30(28)34/h1-17,25-26,32-33H,18H2 | |
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Yes |
General status |
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Rodenticide | |
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Coumarin anticoagulant | |
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970 | |
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EU dossier - none declared | |
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Synthetic | |
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Second generation anticoagulant which blocks prothrombin formation, inhibits blood coagulation | |
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28772-56-7 | |
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249-205-9 | |
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371 | |
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112001 | |
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54680085 | |
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527.40 | |
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3-[(1E,3E)-3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2H-1-benzopyran-2-one | |
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3-[(1RS,3RS;1RS,3SR)-3-(4'-bromobiphenyl-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxycoumarin | |
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3-[3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2H-1-benzopyran-2-one | |
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Not applicable | |
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Not applicable | |
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Not applicable | |
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Not applicable | |
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Odourless white powder |
Formulations |
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Usually supplied in ready-to-use bait formulations such as granules, blocks and pellets |
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18.4 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low | ||||||||
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10000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Ethyl acetate5 = Verified data used for regulatory purposes |
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12000 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Acetone4 = Verified data |
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8200 | C4 C = AGRITOX (click here ) Ethanol4 = Verified data |
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5600 | C4 C = AGRITOX (click here ) Methanol4 = Verified data |
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199 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Decomposes before boiling | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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200 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Not expected to self ignite; Not highly flammable | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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1.17 X 1004 | Calculated | - | |||||||
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4.07 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
High | ||||||||
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4.04 | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) 3 = Unverified data of known source |
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Weak acid | |||||||||||
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2.13 X 10-05 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low volatility | ||||||||
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8.99 X 10-07 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-volatile | ||||||||
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Neutral solution: 206-214nm = 74211, 260-266nm = 29157, 312-314nm = 13895 Acidic solution: 206-214nm = 64736, 250-266nm = 33316, 313-314nm = 12263 Alkaline solution: 206-214nm = 127895, 260-266nm = 28526, 312-314nm = 13895 |
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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71.2 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Degradation |
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53 | C4 C = AGRITOX (click here ) 4 = Verified data |
Moderately persistent | |||||||
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14 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-persistent | ||||||||
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4.6 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Non-persistent | ||||||||
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EU dossier Lab studies DT₅₀ range 2.8-269 days, DT₉₀ range14-658 days | ||||||||||
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0.1 | C4 C = AGRITOX (click here ) 4 = Verified data |
Fast | |||||||
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30 | C4 C = AGRITOX (click here ) 4 = Verified data |
Moderately persistent | |||||||
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Soil adsorption and mobility |
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7.9 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 3 = Unverified data of known source |
Slightly mobile | |||||||
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1636 | ||||||||||
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0.77 | ||||||||||
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EU dossier Kd range 5.3-10.4 mL g⁻¹, Kfoc range 1563-1709 mL g⁻¹, 1/n range 0.652-0.887, Soils=2 | ||||||||||
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Lower adsoption under alkaline conditions than under acidic. |
Fate indices |
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0.52 | Calculated | Low leachability | ||||||||||||||||||||||||||
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3.04 X 10-03 | Calculated | - | |||||||||||||||||||||||||
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High | Calculated | - | ||||||||||||||||||||||||||
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Slightly mobile | Calculated | - |
Other known metabolites |
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3-[(1RS)-3-(4'-bromobiphenyl-4-yl)-3-oxo-1-phenylpropyl]-4-hydroxy-2H-chromen-2-one Note: Moderately persistent |
bromadiolone ketone | Soil | 0.40 | - | |||||
(1RS,3RS)-5-(4'-bromobiphenyl-4-yl)-1,3-diphenylpentan-1-ol | - | Soil | 0.19 | - | |||||
(1RS,3RS,5RS)-1-(4'-bromobiphenyl-4-yl)-3,5-diphenylpentane-1,5-diol | - | Soil | 0.25 | - |
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867 | Q2 Q = Miscellaneous internet resources Estimated2 = Unverified data of unknown source |
Threshold for concern | |||||||
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Not available | - | |||||||||
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> 0.56 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
High | ||||||||
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138 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Colinus virginianus5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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> 8.0 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Oncorhynchus mykiss5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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2 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Daphnia magna5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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0.017 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Scenedemus subspicatus5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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> 4.74 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
High | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 0.56 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
High | ||||||||
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1.30 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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0.0043 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat 4 hr5 = Verified data used for regulatory purposes |
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Not relevant | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 3 = Unverified data of known source |
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Not relevant | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 3 = Unverified data of known source |
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0.0012 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rabbit SF=8574 = Verified data |
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1.6 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Small risk identified from possible bait contact | |||||||||
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Absorbed from the gastrointestinal tract, from intact skin, and the respiratory system - PPE/PPC advised | ||||||||||
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0.016 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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Anticoagulant and may cause haemorrhaging It is very toxic by inhalation, contact with the skin and by ingestion Slight eye irritant |
Handling issues |
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Not oxidising or explosive | |||
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Health: H300, H310, H330, H360d, H372 Environment: H400, H410 |
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Xn - Harmful: R21, R22 | |||
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S13, S21/22, S24, S36/37, S46 | |||
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Ia (Extremely hazardous) | |||
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3027 | |||
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bromadiolone | ||
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bromadiolone | ||
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Bromadiolon | ||
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bromadiolon | ||
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bromadiolone | ||
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bromadiolona | ||
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bromadiolon | ||
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bromadiolon | ||
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bromadiolon |
Record last updated: | 12/01/2021 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |