(Also known as: clofenvinfos; CVP; OMS 1328; ENT 24969; CGA 26351)
SUMMARY
Chlorfenvinphos is a soil-applied insecticide. It has a moderate aqueous solubility and is miscible with many organic solvents. It is relatively volatile and there is some risk that it may leach to groundwater. It is moderately persistent in soil systems. It is highly toxic to mammals, an endocrine distruper, a neurotoxin and an inhibitor of cholinesterase. In addition there is some concern that it may bio-concentrate. Chlorfenvinphos is highly toxic to birds, honeybees and aquatic invertebrates. It is moderately toxic to fish and earthworms.
Data alerts
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
Environmental fate Moderate alert: Moderately persistent; Drainflow: Slightly mobile
Ecotoxicity High alert: Birds acute ecotoxicity: High; Fish chronic ecotoxicity: High; Daphnia acute ecotoxicity: High; Daphnia chronic ecotoxicity: High; Bees acute oral ecotoxicity: High
Human health High alert: Mammals acute toxicity: High; Endocrine distrupter; Acetyl cholinesterase inhibitor; Neurotoxicant
GENERAL INFORMATION
Description
Substance used as a dip or spray to treat ectoparasitic insects, ticks and mites on livestock
Availability status
Current
Introduction & key dates
circa 1962
Examples of species treated
Sheep, Goats, Cattle
Chemical structure
Isomerism
Exists in two geometric isomeric forms: alpha (cis) isomer and beta (trans) isomer.
WFD priority substance; Marine, Surface and Groundwater Pollutant; Chemical subject to PIC regulations; PAN Bad Actor Chemical; Subject to the provisions of the UK Poisons Act 1972
Relevant Environmental Water Quality Standards
EU Directive 2008/105/EC EQS surface waters: annual average 0.1 µg l⁻¹; max measured 0.3 µg l⁻¹
Physical state
Colourless to amber liquid
Formulations
Property
Product
Manufacturer
Authorisation Route
UK Legal Class
Example products using this active
None identified
None identified
No UK authorisation for use with animals
Not applicable
Formulation and application details
Available in a variety of formulations including emulsifiable concentrates, granules, seed treatments and wettable powders.
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
145
B5 B = UK CRD and ACP evaluation documents / and other Defra (UK) documents (click here ) 5 = Verified data used for regulatory purposes
Moderate
Solubility - In organic solvents at 20 °C (mg l⁻¹)
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
-
Degradation point (°C)
-
-
-
Flashpoint (°C)
-
-
-
Octanol-water partition coefficient at pH 7, 20 °C
P
6.31 X 1003
Calculated
-
Log P
3.8
B5 B = UK CRD and ACP evaluation documents / and other Defra (UK) documents (click here ) 5 = Verified data used for regulatory purposes
High
Fat solubility of residues
Solubility
Soluble
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
-
Data type
Observed in metabolism and farm animal feeding studies
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
Dermal and inhalation during pesticide handling Source: US EPA
Mammalian dose elimination route and rate
Majority excreted in the urine, much less in the faeces. Some also lost from the lungs.
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
-
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
No data found
A3 A = Chromosome aberration (EFSA database) 3 = Negative
;
B0 B = DNA damage/repair (EFSA database) 0 = No data
;
C0 C = Gene mutation (EFSA database) 0 = No data
;
D0 D = Genome mutation (EFSA database) 0 = No data
;
E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
✓Yes, known to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
✓Yes, known to cause a problem
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
No data found
No data found
Eye irritant
Phototoxicant
 
No data found
No data found
 
General human health issues
May cause bradycardia or tachycardia May cause Loss of muscle coordination, slurring of speech May cause mental confusion, disorientation and drowsiness Endocrine issues - Weak estrogen effect
Handling issues
Property
Value and interpretation
General
Prevent generation of mists Not expected to autoignite; Not highly flammable
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242