Nicarbazin
Last updated: 12/08/2021
(Also known as: nicarbazine)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
A medicinal feed additive used to treat a protozoan disease - coccidiosis in chickens and for egg hatch reduction in Canada Geese
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2005
Domestic fowl, Canada geese
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C₁₉H₁₈N₆O₆
CC1=CC(=NC(=O)N1)C.C1=CC(=CC=C1NC(=O)NC2=CC=C(C=C2)[N+](=O)[O-])[N+](=O)[O-]
No data
UKHWDRMMMYWSFL-UHFFFAOYSA-N
InChI=1S/C13H10N4O5.C6H8N2O/c18-13(14-9-1-5-11(6-2-9)16(19)20)15-10-3-7-12(8-4-10)17(21)22;1-4-3-5(2)8-6(9)7-4/h1-8H,(H2,14,15,18);3H,1-2H3,(H,7,8,9)
Yes
Coccidiostat, Antiprotozoal agent, Feed additive
Unclassified substance
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Synthetic
Inhibits the formation of the vitelline membrane separating the egg yolk and egg white
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330-95-0
206-359-1
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85712
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QP51AE03
Antiparasitic products, insecticides & repellents: Antiprotozoals
No
No data
426.38
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A complex of two compounds, 4,4'-dinitrocarbanilide (DNC) and 4,6-dimethyl-2-pyrimidinol (HDP)
N,N'-bis(4-nitrophenyl)-urea (DNC), compound with 4,6-dimethyl-2(1H)-pyrimidinone (1:1) (HDP)
Not approved as a feed additive in EU
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Yellow to tan coloured powdery solid
Maxiban G160
Elanco Animal Health
Annex 1 OJ 2004/c50/01
Not applicable
OvoControl-G
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No UK approval for use with animals
Not applicable
Supplied as bait that may be applied with bait pans, broadcast directly on the ground by hand or with mechanical feeders
0.52
Low
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270
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5.75 X 1003
Calculated
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3.76
High
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0.5
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Produces a band of absorption in the range of 300-360mm
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301
Persistent
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The DNC portion degrades slowly in soil with DT₅₀ ~ 1yr & does not volatilize or leach through the soil. DNC and HDP will have different fate profiles
>8
R4 R = Peer reviewed scientific publications 4 = Verified data
Broiler faeces Slightly persistent
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602
Stable
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Stable
Stable
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
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> 3680
Anas platyrhynchos
Low
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> 0.069
Oncorhynchus mykiss for DNC fraction
High
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> 0.093
Daphnia magna for DNC fraction
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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5000
Rat
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> 0.147
Rat
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Metabolised and excreted mainly in the faeces
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
XNo, known not to cause a problem
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
No further information available
Not expected to autoignite; Not highly flammable
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None - not a ppp
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nicarbazin
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Record last updated:
12/08/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242