Narasin |
![]() Last updated: 22/04/2021 |
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(Also known as: (4S)-4-methyl-salinomycin; compound 79891; antibiotic A 28086A ) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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![]() Significant data are missing |
![]() Significant data are missing |
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A coccidiostat and antibacterial agent used as a growth enhancer | |
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Chickens, Cattle |
Chemical structure |
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Isomeric | |
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C₄₃H₇₂O₁₁ | |
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CCC(C1C(CC(C(O1)C(C)C(C(C)C(=O)C(CC)C2C(CC(C3(O2)C=CC(C4(O3)CCC(O4)(C)C5CCC(C(O5)C)(CC)O)O)C)C)O)C)C)C(=O)O | |
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CC[C@H]([C@H]1[C@H](C[C@@H]([C@@H](O1)[C@@H](C)[C@@H]([C@H](C)C(=O)[C@H](CC)[C@@H]2[C@H](C[C@H]([C@]3(O2)C=C[C@H]([C@@]4(O3)CC[C@@](O4)(C)[C@H]5CC[C@@]([C@@H](O5)C)(CC)O)O)C)C)O)C)C)C(=O)O | |
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VHKXXVVRRDYCIK-CWCPJSEDSA-N | |
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InChI=1S/C43H72O11/c1-12-30(35(46)27(8)34(45)28(9)36-23(4)21-24(5)37(51-36)31(13-2)39(47)48)38-25(6)22-26(7)42(52-38)18-15-32(44)43(54-42)20-19-40(11,53-43)33-16-17-41(49,14-3)29(10)50-33/h15,18,23-34,36-38,44-45,49H,12-14,16-17,19-22H2,1-11H3,(H,47,48)/t23-,24-,25-,26+,27-,28-,29-,30-,31+,32+,33+,34+,36+,37+,38-,40-,41+,42-,43-/m0/s1 | |
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Yes |
General status |
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Coccidiostat, Antiobiotic, Antibacterial, Antiparasitic, Growth stimulant, Feed additive | |
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Ionophore | |
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Synthetic | |
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Dissociates the calcium fluxes in muscle fibers | |
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55134-13-9 | |
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QP51AH04 | |
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Antiparasitic products, insecticides & repellents: Antiprotozoals | |
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N/a | |
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No data | |
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765.03 | |
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(2R)-2-[(2R,3S,5S,6R)-6-[(1S,2S,3S,5R)-5- [(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyl-2-tetrahydropyranyl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl]-2-hydroxy-1,3-dimethyl-4-oxoheptyl]-3,5-dimethyl-2-tetrahydropyranyl]butanoic acid | |
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White to off-white, crystalline powder | |
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Formulations |
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Maxiban G160 | Elanco Animal Health E772 | Annex 1 OJ 2004/C50/01 | Not applicable | ||||||
Monteban | Elanco Animal Health E772 | Annex 1 EC.545/2006 | Not applicable | |||||||
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Usually supplied as a feed additive |
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102 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Moderate | ||||||||
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98 | L3 L = Pesticide manuals and hard copy reference books / other sources resolidifies remelts at 1983 = Unverified data of known source |
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Decomposes before boiling | Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source |
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217 | Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source |
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7.08 X 1003 | Calculated | - | |||||||
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3.85 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) at pH84 = Verified data |
High | ||||||||
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7.9 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Ethanol: 285nm | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Degradation |
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8.8 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Non-persistent | |||||||
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8.8 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Greenhouse conditions3 = Unverified data of known source |
Non-persistent | ||||||||
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4.2 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Non-persistent | ||||||||
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1.5 | F2 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 2 = Unverified data of unknown source |
Moderately fast | |||||||
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Susceptible to photolysis | ||||||||||
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Stable | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Stable | |||||||
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Stable pH 7 and 9, DT₅₀ 3.5 days at pH 5 | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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hydroxynarasin | - | Animal (Liver) | - | - | |||||
trihydroxynarasin | - | Animal (Liver) | - | - | |||||
dihydroxynarasin | - | Animal (Liver) | - | - | |||||
9-keto-trihydroxynarasin | - | Animal (Liver) | - | - |
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Terrestrial ecotoxicology |
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21.2 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
High | ||||||||
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75.57 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Colinus virginianus4 = Verified data |
High | ||||||||
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> 20 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Lumbricus terrestris3 = Unverified data of known source |
Moderate | ||||||||
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0.5 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Moderate | ||||||||
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Aquatic ecotoxicology |
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> 3.27 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Lepomis macrochirus4 = Verified data |
Moderate | ||||||||
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0.033 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Lepomis macrochirus4 = Verified data |
Moderate | ||||||||
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> 7.72 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna4 = Verified data |
Moderate | ||||||||
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0.077 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna4 = Verified data |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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21.2 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
High | ||||||||
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Intravenous LD₅₀ = 1.96 mg kg⁻¹ | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 7.0 mg kg⁻¹ | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) Mouse3 = Unverified data of known source |
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Rapidly metabolised in liver and eliminated in faeces | Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source |
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Health issues |
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May cause behavioural and gastrointestinal problems |
Handling issues |
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IMDG Transport Code is usually 6.1a | |||
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None - not a ppp | |||
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2811 | |||
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Packaging Group II (medium danger) |
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narasin | ||
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narasine | ||
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narasino | ||
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Record last updated: | 22/04/2021 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |