Sulfadiazine
Last updated: 21/06/2023
(Also known as: adiazine; diazolone; SDZ; SDA; sulfanilamidopyrimidine; sulfapyrimidine)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
A commonly used synthetically produced livestock antibiotic / antimicrobial with antiparasitic properties
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circa 1935, discovered
Dogs, Cats, Horses, Cattle, Poultry, Pigs
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C₁₀H₁₀N₄O₂S
C1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
No data
SEEPANYCNGTZFQ-UHFFFAOYSA-N
InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
sulfadiazine
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Antiparasitic, Antibacterial, Coccidiostat, Antiprotozoal
Sulfonamide
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Synthetic
Inhibits the production of folic acid necessary for the growth and multiplication of bacteria
[Dihydropteroate synthetase, antagonist]
68-35-9
200-685-8
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-
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QJ01EW10
Antiinfectants for systemic use: Antibacterials for systemic use
No
Allowed substance (Table 1: All food producing species)
250.278
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4-amino-N-pyrimidin- 2-yl-benzenesulfonamide
4-amino-N-2-pyrimidinylbenzenesulfonamide
Potential groundwater pollutant
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White to slightly yellow crystalline powder
Cotrimoxgen Tablets
Norbrook Labs
UK National authorisation (IC)
Prescription only medicine to be authorised by a veterinarian (POM-V)
Norodine 80mg Tablets
Norbrook Labs
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Trimacare 24% Solution for injection
Norbrook Labs
UK National authorisation (IC)
Prescription only medicine to be authorised by a veterinarian (POM-V)
Equibactin vet.
Le Vet B.V.
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied as tablets or in formulations for preparation as injection solutions
130
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Moderate
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252
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Decomposes before boiling
R4 R = Peer reviewed scientific publications 4 = Verified data
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8.13 X 10-01
Calculated
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-0.09
R4 R = Peer reviewed scientific publications 4 = Verified data
Low
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2.49
R4 R = Peer reviewed scientific publications 4 = Verified data
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pKa(2) = 6.48
5.73 X 10-03
Low volatility
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Stable
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Stable
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5.5
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Fast
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Soil adsorption and mobility
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R4 R = Peer reviewed scientific publications 4 = Verified data
Moderately mobile
81
General literature states Koc range 37-125 mL g⁻¹
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Known soil and groundwater metabolites
None
N4-acetyl-sulfadiazine
Ac-SDZ
Animals (Urine)
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Terrestrial ecotoxicology
1500
Mouse
Moderate
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> 57
Daphnia magna
Moderate
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7.8
R4 R = Peer reviewed scientific publications 4 = Verified data
Selenastrum capricornutum
Moderate
< 1.00
R4 R = Peer reviewed scientific publications 4 = Verified data
Selenastrum capricornutum
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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1500
Mouse
Moderate
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Intraperitoneal LD₅₀ = 750 mg kg⁻¹
Mouse
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Intravenous LD₅₀ = 880 mg kg⁻¹
Rat
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Largely excreted in the urine
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
?Possibly, status not identified
No data found
 
Possible kidney and renal system toxicant
IMDG Transport Hazard Class 6.1
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Not listed (Not listed)
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Packaging Group III (minor danger)
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sulfadiazine
sulfadiazine
Sulfapyrimidin
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sulfadiazina
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Record last updated:
21/06/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242