Acepromazine maleate
Last updated: 30/08/2023
(Also known as: acetylpromazine maleate; ACP; ACE)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A veterinary treatment used as a premedication for quietening and calming animals. It also has antihistamine effects.
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1950's, first use in humans; late 1960's veterinary applications
Horses, Dogs, Cats, Elephants, Deer
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C₂₃H₂₆N₂O₅S
CC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN(C)C.C(=CC(=O)O)C(=O)O
CC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN(C)C.C(=C/C(=O)O)\C(=O)O
FQRHOOHLUYHMGG-WLHGVMLRSA-N
InChI=1S/C19H22N2OS.C4H4O4/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19;5-3(6)1-2-4(7)8/h4-5,7-10,13H,6,11-12H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
Yes
Tranquiliser, Antihistamine
Phenothiazine neuroleptic
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Synthetic
Has a depressant effect on the central nervous system and therefore causes sedation. Dopamine antagonist.
[D(2) dopamine receptor, antagonist], [D(1A) dopamine receptor, antagonist], [5-hydroxytryptamine 2A receptor, antagonist], [5-hydroxytryptamine 1A receptor, antagonist], [Alpha-1A adrenergic receptor, antagonist], [Alpha-1B adrenergic receptor, antagonist]
3598-37-6
222-748-9
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6420038
QN05AA04
Nervous system: Antipsychotics
No
No data
442.50
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(E)-but-2-enedioic acid;1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanone
10-(3-dimethylaminopropyl)phenothiazine-2-yl methyl hydrogen maleate
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Yellow, crystalline powder
ACP (injections/Tablets)
Novartis Animal Health
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Large animal immobilion solution for injection
Novartis Animal Health
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Sedaline 35 mg/ml Oral Gel
Vetoquinol UK Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Oralject Sedazine Acepromazine (1.20% w/v) Oral Paste Tranquilliser for Horses
Vetsearch International (UK) Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied as a solution for injection or in tablet form
37000
High
333000
Chloroform
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77000
Methanol
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135
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497
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254.4
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
2-(1-hydroxyethyl)promazine sulfoxide Note: C19H24N2O2S; Mwt = 344.47
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Animal
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Terrestrial ecotoxicology
400
Rat
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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400
Rat
Moderate
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Subcutaneous LD₅₀ = 65 mg kg⁻¹
Mouse
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Intravenous LD₅₀ = 95 mg kg⁻¹
Rat
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Metabolised by liver, excreted in urine
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
XNo, known not to cause a problem
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
✓Yes, known to cause a problem
?Possibly, status not identified
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
May affect heart and respiratory rate leading to hypotension Ingestion may cause gastrointestinal disturbances
When heated to decomposition it emits highly toxic fumes of NOx and SOx
Health: H317
Not listed (Not listed)
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acepromazine maleate
maléate d'acépromazine
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maleato de acepromazina
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Record last updated:
30/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242