Danofloxacin mesylate
Last updated: 08/04/2021
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
A broad spectrum antibacterial and antimicrobial veterinary treatment for use on cattle, pigs and chickens
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Cattle, Pigs, Domestic fowl
Isomeric
C₂₀H₂₄FN₃O₆S
CN1CC2CC1CN2C3=C(C=C4C(=C3)N(C=C(C4=O)C(=O)O)C5CC5)F.CS(=O)(=O)O
CN1C[C@@H]2C[C@H]1CN2C3=C(C=C4C(=C3)N(C=C(C4=O)C(=O)O)C5CC5)F.CS(=O)(=O)O
APFDJSVKQNSTKF-FXMYHANSSA-N
InChI=1S/C19H20FN3O3.CH4O3S/c1-21-7-12-4-11(21)8-22(12)17-6-16-13(5-15(17)20)18(24)14(19(25)26)9-23(16)10-2-3-10;1-5(2,3)4/h5-6,9-12H,2-4,7-8H2,1H3,(H,25,26);1H3,(H,2,3,4)/t11-,12-;/m0./s1
Yes
Antibacterial, Antimicrobial
Fluoroquinolone
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Synthetic
Inhibits DNA gyrase and triggers induction of the SOS response and temperate bacteriophages
[DNA gyrase subunit A, antagonist]
119478-55-6
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QJ01MA92
Antiinfectants for systemic use: Antibacterials for systemic use
No
Allowed substance (Table 1: All food producing species)
453.48
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(1S)-1-cyclopropyl-6-fluoro-1,4-dihydro-7-(5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl)-4-oxo-3-quinoline carboxylic acid methanesulphonate
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White to off-white crystalline powder
Advocin Solution 180mg/ml injection for cattle
Pfizer Ltd
EU mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Advocin Solution 12.5% injection
Pfizer Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied as a solution for injection
190000
High
100
Ethanol
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100
Acetone
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338
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Acidic solution: Max @ 282nm Basic solution: Max @ 278nm
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115
R4 R = Peer reviewed scientific publications 4 = Verified data
Persistent
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Literature values DT₅₀ range 87-143 mL g⁻¹
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
> 2000
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Rat
Low
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> 100
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Cyprinodon variegatus
Low
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> 63.5
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Daphnia magna
Moderate
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> 100
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Americamysis bahia
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 2000
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Rat
Low
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In rats, dogs and pigs it is excreted in the unchanged form in the urine
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
XNo, known not to cause a problem
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
May cause gastrointestinal problems
No information available
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None - not a ppp
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danofloxacin mesylate
mesilate de danofloxacine
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mesilato de danofloxacino
mesilato de danofloxacino
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Record last updated:
08/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242