Fenbendazole (Ref: Hoe 881v)
Last updated: 14/04/2021
(Also known as: phenbendasol)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
A broad spectrum anthelmintic used against gastrointestinal parasites in livestocks and domestic pets
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Cattle, Sheep, Horses, Domestic pets, Hedgehogs, Bears, Elephants, Pigeons, Exotic birds, Ferrets, Fish
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C₁₅H₁₃N₃O₂S
COC(=O)NC1=NC2=C(N1)C=C(C=C2)SC3=CC=CC=C3
No data
HDDSHPAODJUKPD-UHFFFAOYSA-N
InChI=1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)
Yes
Anthelmintic, Antiparasitic, Nematicide
Benzimidazole
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Synthetic
Binds to tubulin, a protein required for functions including nutrient uptake, thus disrupting parasite energy metabolism
[Tubulin alpha-3 chain, antagonist]
43210-67-9
256-145-7
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QP52AC13
Antiparasitic products, insecticides & repellents: Anthelmintics
No
Allowed substance (Table 1: Ruminants, Porcine, Equidae)
299.35
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methyl N-(6-phenylsulfanyl-1H-benzoimidazol-2-yl)carbamate
2-(methoxycarbonylamino)-5-(phenylthio)benzimidazole
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White to dirty white coloured crystalline powder
Beaphar Worming Granules for Cats & Kittens
Sinclair Animal & Household Care Ltd
UK National authorisation (IC)
Authorised veterinary medicine for general sale (AVM - GSL)
Fenzol 5% Oral Suspension
Norbrook Labs
UK National authorisation
Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Panacur 1.5% pellets
Intervet Ltd
UK National authorisation
Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Wormazole 880mg Granules for Dogs
Norbrook Labs
UK National authorisation
For non-food animal use and may be supplied without a prescription by a suitable qualified person (NFA-VPS)
Various preparations are available for oral administration
0.01
Low
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233
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Decomposes on melting
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7.08 X 1003
Calculated
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3.85
High
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1.40
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Max absorption at 296nm
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0.53
Fast
Slight variation with pH: 0.71 days at pH5 & 0.47 days at pH9
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Soil adsorption and mobility
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R4 R = Peer reviewed scientific publications 4 = Verified data
Mobile
46
General literature states Koc range 35-57 mL g⁻¹
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Known soil and groundwater metabolites
None
Terrestrial ecotoxicology
> 10000
Rat
Low
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1068
Eisenia foetida
Low
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0.04
Oncorhynchus mykiss
High
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0.0165
R4 R = Peer reviewed scientific publications 4 = Verified data
Daphnia magna
High
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 10000
Rat
Low
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Intraperitoneal LD₅₀ > 1250 mg kg⁻¹
Rat
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Subcutaneous LD₅₀ > 2000 mg kg⁻¹
Rat
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Slow adsorption, excreted mainly unchanged in the faeces
Q4 Q = Miscellaneous internet resources 4 = Verified data
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E2 E = Unspecified genotoxicity type (miscellaneous data source) 2 = Mixed/ambiguous results
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
No further information available
Light sensitive
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None - not a ppp
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fenbendazole
fenbendazole
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fenbendazol
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Record last updated:
14/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242