Alphaxalone
Last updated: 17/08/2023
(Also known as: alfaxalone; alfatesine; althesin)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
An injectable anaesthetic agent for induction and maintenance of general anaesthesia in dogs and cats
Current
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Dogs, Cats
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C₂₁H₃₂O₃
CC(=O)C1CCC2C1(CC(=O)C3C2CCC4C3(CCC(C4)O)C)C
CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC(=O)[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@H](C4)O)C)C
DUHUCHOQIDJXAT-OLVMNOGESA-N
InChI=1S/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14+,15-,16+,17-,19+,20-,21+/m0/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
alphaxalone
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Anesthetic, Medicinal drug
Unclassified substance
>98%
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Synthetic
A neurosteroid which acts upon the GABAA receptor
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23930-19-0
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-
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QN01AX05
Nervous system: Anesthetics
No
No data
332.48
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3-hydroxypregnane-11,20-dione
(3α,5α)-3-hydroxypregnane-11,20-dione
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White or off-white coloured powder
Alfaxan 10 mg/l solution of Injection
Vetoquinol UK Ltd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied as a solution for injection
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5.0
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Chloroform
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172
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468
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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251
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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-
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-
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-
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1.112
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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-
-
-
-
-
-
-
-
-
-
-
-
-
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1.532
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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-
-
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-
-
-
-
-
-
-
-
-
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
297
Rat
Moderate
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-
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HUMAN HEALTH AND PROTECTION
High (class III)
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297
Rat
Moderate
2200
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
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Intraperitoneal LD₅₀ = 116 mg kg⁻¹
Rat
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Intravenous LD₅₀ = 19.4 mg kg⁻¹
Rat
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Poison by ingestion, intravenous, and intraperitoneal routes.
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Very short half life in dogs and cats. Excreted in its parent form through the kidneys
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
XNo, known not to cause a problem
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
XNo, known not to cause a problem
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
Toxic if swallowed Associated with acute attacks of porphyria
Dusts may form an explosive mixture with air Use dry powder, foam, sand, carbon dioxide, water mist to fight fires IMDG Transport Hazard Class 6.1
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Not listed (Not listed)
UN2811
Packaging Group III (minor danger)
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alphaxalone
alfaxalone
Alfaxalone
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alfaxalona
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Record last updated:
17/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242