Alfaxalone |
Last updated: 18/05/2024 |
(Also known as: alphaxalone; alfatesine; althesin) |
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An injectable anaesthetic agent for a wide variety of animals | |
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Current | |
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1971, first introduced | |
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Used for the induction and maintenance of general anaesthesia | |
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Dogs; Cats; Sheep; Pigs; Turtles; Rabbits; Horses; Iguanas; Koi carp |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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- | |
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C₂₁H₃₂O₃ | |
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CC(=O)C1CCC2C1(CC(=O)C3C2CCC4C3(CCC(C4)O)C)C | |
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CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC(=O)[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@H](C4)O)C)C | |
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DUHUCHOQIDJXAT-OLVMNOGESA-N | |
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InChI=1S/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14+,15-,16+,17-,19+,20-,21+/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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alfaxalone | - |
General status |
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Anaesthetic, Medicinal drug | |
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Unclassified substance | |
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>98% | |
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Synthetic | |
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A neurosteroid which acts upon the GABA-A receptor | |
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[GABA A receptor, Agonist] | |
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23930-19-0 | |
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636-625-6 | |
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104845 | |
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Nervous system: Anesthetics | |
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QN01AX05 | |
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No | |
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332.48 | |
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- | |
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3-hydroxypregnane-11,20-dione | |
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(3α,5α)-3-hydroxypregnane-11,20-dione | |
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- | |
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White or off-white coloured powder |
Formulations |
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Alfaxan 10 mg/l solution of Injection | Zoetis UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Usually supplied as a solution for injection |
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5.0 | R3 R = Peer reviewed scientific publications Chloroform3 = Unverified data of known source |
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172 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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468 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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251 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.112 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.532 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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297 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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297 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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2200 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 116 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 19.4 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Poison by ingestion, intravenous, and intraperitoneal routes. | |||||||||
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Very short half life in dogs and cats. Excreted in its parent form through the kidneys | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
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Health issues |
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Toxic if swallowed Associated with acute attacks of porphyria |
Handling issues |
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Dusts may form an explosive mixture with air Use dry powder, foam, sand, carbon dioxide, water mist to fight fires IMDG Transport Hazard Class 6.1 |
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Not listed (Not listed) | |||
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UN2811 | |||
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Packaging Group III (minor danger) | |||
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alfaxalone | ||
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alfaxalone | ||
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Alfaxalone | ||
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alfaxalona | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |