Enrofloxacin (Ref: BAY VP 2674)
Last updated: 14/04/2021
(Also known as: BRN 5307824)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
A broad-spectrum bactericidal antibiotic used to treat domesticated animals for a variety of infections including E.coli., Enterobacter, Campylobacter, Shigella and Salmonella
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Domestic animals including: Dogs, Cats, Rabbits, Horses. May also be used on Reptiles, Poultry and Cattle.
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C₁₉H₂₂FN₃O₃
CCN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4CC4)F
No data
SPFYMRJSYKOXGV-UHFFFAOYSA-N
InChI=1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
enrofloxacin
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Antibiotic, Chemotherapeutic agent, Medicinal drug, Bactericide
Fluoroquinolone
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Synthetic
Not clear but believed to act by inhibiting bacterial DNA gyrase
[DNA gyrase subunit A, antagonist], [DNA topoisomerase 2-alpha, antagonist]
93106-60-6
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QJ01MA90
Antiinfectants for systemic use: Antibacterials for systemic use
No
Allowed substance (Table 1: All food producing species)
359.4
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1,4-dihydro-1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-4-oxo-3-quinolinecarboxylic acid
1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
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Pale yellow crystalline powder
Baytril 10% Oral Solution
Bayer plc
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Enrocare 100mg/ml Solution for Injection for Cattle and Pigs
LeVet Pharma B.V.
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Enrox Flavour 15mg Tablets for Dogs & Cats
KrKa Dd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Xeden 15mg Tablets for Cats
Sogeval S.A.
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Available in a variety of forumulations including solution for injection, powders and tablets
130000
R4 R = Peer reviewed scientific publications 4 = Verified data
High
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220
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5.01 X 1004
Calculated
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4.7
R4 R = Peer reviewed scientific publications 4 = Verified data
High
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6.21
R4 R = Peer reviewed scientific publications 4 = Verified data
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2.53 X 10-08
Low volatility
3.2 X 10-08
R4 R = Peer reviewed scientific publications 4 = Verified data
Non-volatile
Max @ 270+1nm and 314+2nm
R4 R = Peer reviewed scientific publications 4 = Verified data
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123
Persistent
297
Persistent
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DT₅₀ range 99-149 days, DT₉₀ range 330-495 days; Industry data DT₅₀ 359-696 days (R3)
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Soil adsorption and mobility
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R4 R = Peer reviewed scientific publications 4 = Verified data
Non-mobile
392600
Koc range 16506-768740 mL g⁻¹
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-3.94
Calculated
Low leachability
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Known soil and groundwater metabolites
None
Terrestrial ecotoxicology
> 5000
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Rat
Low
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> 10
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Lepomis macrochirus
Moderate
~ 1
Pimephales promelas 7 day
Moderate
> 100
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Daphnia magna
Low
~ 1.0
Daphnia magna 48hr
Moderate
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> 0.084
Lemna gibba
Moderate
> 2.6
Pseudokirchneriella subcapitata
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 5000
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Rat
Low
2000
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Rat
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> 35.47
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Rat 4 hr
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Intravenous LD₅₀ = 200 mg kg⁻¹
Mouse
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Eliminated by both renal and hepatic metabolism
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
No data found
XNo, known not to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause gastrointestinal disturbances
Light sensitive
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None - not a ppp
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enrofloxacin
enrofloxacine
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enrofloxacino
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Record last updated:
14/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242