Orbifloxacin
Last updated: 30/06/2022
(Also known as: obixacin)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Used to treat a variety of infections, including urinary tract infections, respiratory infections and wound infections caused by susceptible bacteria
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Dogs, Cats
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C₁₉H₂₀F₃N₃O₃
CC1CN(CC(N1)C)C2=C(C3=C(C(=C2F)F)C(=O)C(=CN3C4CC4)C(=O)O)F
C[C@@H]1CN(C[C@@H](N1)C)C2=C(C3=C(C(=C2F)F)C(=O)C(=CN3C4CC4)C(=O)O)F
QIPQASLPWJVQMH-DTORHVGOSA-N
InChI=1S/C19H20F3N3O3/c1-8-5-24(6-9(2)23-8)17-14(21)13(20)12-16(15(17)22)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6H2,1-2H3,(H,27,28)/t8-,9+
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
orbifloxacin hemihydrate
hemihydrate
Antibiotic, Antibacterial, Antimicrobial, Medicinal drug
Fluoroquinolone
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Synthetic
Broad spectrum, acts by deactivating bacterial enzymes necessary for the transcription of DNA
[DNA gyrase subunit A, antagonist]
113617-63-3
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QJ01MA95
Antiinfectants for systemic use: Antibacterials for systemic use
N
No data
395.37
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1-cyclopropyl-7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
1-cyclopropyl-5,6,8-trifluoro-1,4-dihydro-7-(cis-3,5-dimethyl-1-piperazinyl)-4-oxo-quinoline-3-carboxylic acid
Evidence of use in third world countries
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Orbax Oral Suspension 30 mg/ml for Dogs and Cats
Schering-Plough Ltd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Posatex ear drops suspension for dogs
Intervet International BV
EU centralised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Orbax 68mg Tablets
Schering-Plough Ltd
No UK approval for use
Not applicable
Available in tablet form and as oral suspensions flavoured to make them more palatable
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259
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
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5.95
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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pKa(2) = 9.01
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
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HUMAN HEALTH AND PROTECTION
High (class III)
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It is around 95% absorbed and eliminated by the kidneys 50% unchanged.
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
XNo, known not to cause a problem
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
XNo, known not to cause a problem
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
✓Yes, known to cause a problem
 
May cause decreased appetite, diarrhoea and restlessness
No information available
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Not listed (Not listed)
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orbifloxacin
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Record last updated:
30/06/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242