Cyclosporin |
![]() Last updated: 30/08/2023 |
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(Also known as: cyclosporin A; CsA; cyclosporine; antibiotic S 7481F1 ; ciclosporin) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
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An animal health drug used mainly to treat autoimmune diseases in dogs and cats. It is also used to used to treat dry eye conditions and pannus in dogs. | |
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1971, discovered | |
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Dogs, Cats |
Chemical structure |
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C₆₂H₁₁₁N₁₁O₁₂ | |
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CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C | |
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CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C | |
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PMATZTZNYRCHOR-CGLBZJNRSA-N | |
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InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1 | |
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Yes |
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Common Name | Relationship | Link |
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cyclosporin A | - | ![]() |
General status |
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Medicinal drug; Fungicide | |
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Diderophore | |
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98% | |
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Synthetic | |
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Prevents the dephosphorlyation of NF-AT by binding to cyclophilin | |
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[Calcium signal-modulating cyclophilin ligand, binder], [pCalcineurin subunit B isoform 2, antagonist], [Peptidyl-prolyl cis-trans isomerase A] | |
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59865-13-3 | |
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5280754 | |
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QL04AD01; QS01XA18 | |
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Antineoplastic & immunomodulating agents: Immunosuppressants; Sensory Organs: Ophthalmologicals | |
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No | |
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No data | |
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1202.61 | |
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(E)-14,17,26,32-tetrabutyl-5-ethyl-8-(1-hydroxy-2-methylhex-4-enyl) -1,3,9,12,15,18,20,23,27-nonamethyl-11,29-dipropyl-1,3,6,9,12,15,18,21,24,27,30- undecaazacyclodotriacontan-2,4,7,10,13,16,19,22,25,28,31-undecaone | |
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Liquid |
Formulations |
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Atopica 10 mg soft capsules for dogs | Novartis Animal Health | EU Mutually recognised procedure | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Atopica 100 mg soft capsules for dogs | Novartis Animal Health | EU Mutually recognised procedure | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Optimmune Ophthalmic Ointment 2mg/g Eye ointment | Schering-Plough Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Available in a variety of formulations including ointments and tablets for oral administration |
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200000 | Q3 Q = Miscellaneous data from online sources Ethanol3 = Unverified data of known source |
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100000 | Q3 Q = Miscellaneous data from online sources DMSO3 = Unverified data of known source |
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150 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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8.32 X 1002 | Calculated | - | |||||||
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2.92 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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60 | R4 R = Peer reviewed scientific publications Composed soil4 = Verified data |
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
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Other known metabolites |
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- | Metabolite AM1; cyclosprorin M17 | Human (Liver) | - | Cytochrome P450 3A4 | |||||
- | Metabolite AM4N | Human (Liver) | - | - | |||||
- | Metabolite AM9 | Human (Liver) | - | - |
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Terrestrial ecotoxicology |
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> 1480 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 1480 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 147 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Subcutaneous LD₅₀ = 286 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Extensively metabolised in the liver and excreted in human bile, feces, blood, & urine. Excreted into human breast milk | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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Possible liver and kidney toxicant May cause gingival hyperplasia, convulsions, peptic ulcers, pancreatitis, fever Ingestion can cause vomiting, diarrhoea, confusion & hypercholesterolemia |
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No further information available | |||
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Not listed (Not listed) | |||
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cyclosporin | ||
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ciclosporine | ||
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ciclosporina | ||
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Record last updated: | 30/08/2023 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |