Frusemide
Last updated: 17/08/2023
(Also known as: furosemide)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A diuretic used in the treatment of congestive heart failure, pulmonary edema, kidney disease, high blood pressure and edema in a range of animals
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circa 1970
Horses, Cats, Dogs, Cattle
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C₁₂H₁₁ClN₂O₅S
C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl
No data
ZZUFCTLCJUWOSV-UHFFFAOYSA-N
InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
frusemide
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Diuretic, Antihypertensive
Sulfonamide
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Synthetic
Blocks the absorption of salt and fluid in the kidney tubules, causing diuresis.
[Solute carrier family 12 member 1, blocker]
54-31-9
200-203-6
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QC03CA01
Cardiovascular system: Diuretics
No
Allowed substance (Table 1: All food producing species)
330.75
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4-chloro-2-(furan-2-ylmethylamino)- 5-sulfamoylbenzoic acid
2-furfurylamino-4-chloro-5-sulfamoylbenzoic acid
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Pale yellow powder
Frusecare 40 mg Tablets
Dechra Ltd
UK National authorisation (IC)
Prescription only medicine to be authorised by a veterinarian (POM-V)
Frusecare oral 40 mg Tablets
Dechra Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Dimazon 5% w/v solution for injection
Intervet UK Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Furosemide Tablets B.P. (Vet) 40mg
Millpledge Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Available in a variety of formulations including solutions for injection and tablets for oral administration
73.1
Moderate
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295
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1.07 X 1002
Calculated
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2.03
Low
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4.30 X 10-05
Low volatility
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In ethanol: 288nm, 276nm, 336nm In NaOH: 226nm, 273nm, 336nm
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
4-chloro-5-sulfamoylanthranilic acid Note: Minor metabolite
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Human (Liver)
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Terrestrial ecotoxicology
> 2600
Rat
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 2600
Rat
Low
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Subcutaneous LD₅₀ = 4600 mg kg⁻¹
Rat
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Intraperitoneal LD₅₀ = 800 mg kg⁻¹
Rat
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Excreted largely unchanged in the urine
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
kidney, liver, bladder, cardiovascular system toxicant
Do not use water jets to fight fires, use dry chemical, foam or water spray
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Not listed (Not listed)
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frusemide
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furosemida
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furosemidu
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Record last updated:
17/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242