Triclabendazole (Ref: CGA 89317)
Last updated: 26/04/2021
(Also known as: CGA 89317)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
Oral anthelmintic for the control of liver flukes in cattle, sheep and goats
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Cattle, Sheep, Goats
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C₁₄H₉Cl₃N₂OS
CSC1=NC2=CC(=C(C=C2N1)Cl)OC3=C(C(=CC=C3)Cl)Cl
No data
NQPDXQQQCQDHHW-UHFFFAOYSA-N
InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
triclabendazole
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Anthelmintic, Antiparasitic Medicinal drug
Benzimidazole
>97%
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Synthetic
It binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.
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68786-66-3
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-
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QP52AC01
Antiparasitic products, insecticides & repellents: Anthelmintics
No
Allowed substance (Table 1: Ruminants)
359.66
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5-chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole
6-chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole
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White to brown crystalline powder
Combinex Cattle Oral Suspension
Novartis Animal Health
UK National authorisation
Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Endofluke 100 mg/ml Oral Suspension
Cross VetPharm Group
EU Mutually recognised procedure
Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Tribex 10% Oral Suspension for Cattle
Chanelle Animal Health
EU Mutually recognised procedure
Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Triclafas Drench 5% w/v Oral Suspension
Norbrook Labs
UK National authorisation
Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Usually formulated for oral administration
1.0
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Low
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-
-
175
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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496
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
-
-
-
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253.7
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
-
-
-
-
-
-
-
-
-
-
-
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1.59
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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-
-
-
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-
-
-
-
-
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-
-
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1.724
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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-
-
-
-
-
-
-
-
-
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
2-benzimidazolone
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Animal (Urine and Faeces)
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-
triclabendazole sulfoxide
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Animal (Faeces)
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-
triclabendazole sulfone
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Animal (Faeces)
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4-hydroxy triclabendazole
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Animal (Faeces)
-
-
Terrestrial ecotoxicology
> 5000
Rat
Low
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-
-
-
-
-
-
-
-
-
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-
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0.14
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Oncorhynchus mykiss
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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-
> 5000
Rat
Low
4000
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
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> 0.5
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat 4 hr
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Mostly metabolised and excreted via urine and faeces. Also identified unchanged in breast milk.
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Possible liver and kidney toxicant
No information available
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Not listed (Not listed)
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triclabendazole
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triclabendazol
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Record last updated:
26/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242