Phenylbutazone
Last updated: 21/06/2023
(Also known as: bute; chembutazone ; butazolidine)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
A non-steroidal anti-inflammatory drug (NSAID) for the treatment of chronic pain, including the symptoms of arthritis in horses, cats and dogs
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Horses, Dogs, Cats
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C₁₉H₂₀N₂O₂
CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3
No data
VYMDGNCVAMGZFE-UHFFFAOYSA-N
InChI=1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
phenylbutazone
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Analgesic, Anti-inflammatory
Phenylhydrazine
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Synthetic
Binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues.
[Prostaglandin G/H synthase 2, antagonist], [Prostacyclin synthase, antagonist], [Prostaglandin G/H synthase 1, antagonist]
50-33-9
200-029-0
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QM01AA01; QM02AA01
Musculo-skeletal system: Anti-inflammatory and antirheumatic products, Topical products for joint and muscular pain
No
No data
308.37
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4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione
3,5-dioxo-1,2-diphenyl-4-N-butylpyrazolidine
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Powdery solid
Companazone 25 mg Coated Tablets
Arnolds Veterinary Products
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Equipalazone 1 g Oral Paste
Dechra Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Phenylbentazone Tablets
JM Loveridge plc
UK National authorisation (IC)
Prescription only medicine to be authorised by a veterinarian (POM-V)
Pro-Dynam Oral Powder, 1 g phenylbutazone per sachet
Dechra Veterinary Products
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually formulated for oral administration
47.5
Low
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105
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3.16 X 1004
Calculated
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4.5
High
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4.5
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
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3.95 X 10-05
Low volatility
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In methanol: 239.5nm
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
4-butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione
oxyphenbutazone
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Terrestrial ecotoxicology
245
Rat
Moderate
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> 100
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Danio rerio
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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245
Rat
Moderate
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Intraperitoneal LD₅₀ = 142 mg kg⁻¹
Rat
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Intramuscular LD₅₀ = 220 mg kg⁻¹
Rat
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Metabolised in the liver and excreted in the urine
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause stomach irritation and vomiting
IMDG Transport Hazard Class 6.1
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Not listed (Not listed)
UN2811
Packaging Group III (minor danger)
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phenylbutazone
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Phenylbutazon
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fenilbutazona
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Record last updated:
21/06/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242