Neomycin (Ref: USAF CB-19)
Last updated: 16/03/2023
(Also known as: fradiomycin; neomycine; nivemycin; mycifradin)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A topically applied, broad spectrum antibiotic effective against a wide range of bacteria in dogs, cats and other animals
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1949, discovered
Cats, Dogs, Fish, Cattle, Pigs, Sheep
Isomeric
C₂₃H₄₆N₆O₁₃
C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N
C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N
PGBHMTALBVVCIT-VCIWKGPPSA-N
InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
Yes
Medicinal drug, Antibiotic; Antibacterial
Aminoglycoside
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Natural
Inhibits bacteria by suppressing protein synthesis and growth.
[30S ribosomal protein S12, antagonist], [16S rRNA, antagonist]
1404-04-2
215-773-1
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006303
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QA07AA51
Alimentary tract & metabolism: Intestinal anti-infectants
No
Allowed substance (Table 1: All food producing species)
614.64
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(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-ß-L-idopyranosyl)- ß-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-a-D-glucopyranoside
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Pale yellow coloured solid
Bimamix, Oral Suspension for Calves
Cross Vetpharm Group Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Bovilis Huskvac
Intervet UK Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Quantum Cat CVRP
Intervet UK Ltd
UK National authorisation (IC)
Prescription only medicine to be authorised by a veterinarian (POM-V)
Vanguard Rabies
Pfizer Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Available in a variety of formulations including ear drops, oral powders & suspensions, tablets and solutions for injection.
250
Moderate
0.225
Methanol
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0.095
Ethanol
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0.05
Benzene
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0.08
Cyclohexane
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255
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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255
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2.00 X 10-04
Calculated
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-3.7
R4 R = Peer reviewed scientific publications 4 = Verified data
Low
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12.9
R4 R = Peer reviewed scientific publications 4 = Verified data
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4.1 X 10-08
R4 R = Peer reviewed scientific publications 4 = Verified data
Non-volatile
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1.541
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
> 200
Rat
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 200
Rat
Moderate
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Intraperitoneal LD₅₀ = 116 mg kg⁻¹
Mouse
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Subcutaneous LD₅₀ = 633 mg kg⁻¹
Rat
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Up to 97% of oral dose excreted unchanged in faeces
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
✓Yes, known to cause a problem
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Kidney toxicant May cause dermatitis May impair hearing or cause vertigo
When heated to decomposition it emits acrid smoke & irritating fumes
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Not listed (Not listed)
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neomycin
neomycine
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Record last updated:
16/03/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242