Clindamycin
Last updated: 30/08/2023
(Also known as: 7(S)-chloro-7-deoxylincomycin; chlolincocin; chlorlincocin; U-21251)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
Used primarily to treat infections caused by susceptible anaerobic bacteria and is effective against bacteria that infect the skin, oral cavity, bone and respiratory tract
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Dogs, Cats
Isomeric
C₁₈H₃₃ClN₂O₅S
CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)Cl
CCC[C@@H]1C[C@H](N(C1)C)C(=O)NC([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@H](C)Cl
KDLRVYVGXIQJDK-GOBYPPTJSA-N
InChI=1S/C18H33ClN2O5S/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25)/t9-,10+,11-,12+,13-,14+,15+,16+,18+/m0/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
Clindamycin hydrochloride monohydrate
Variant
Antibiotic, Antibacterial, Medicinal drug
Lincosamide
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Semi-synthetic
A bacterial protein synthesis inhibitor that works by inhibiting ribosomal translocation
[50S ribosomal protein L10, antagonist], [23S rRNA, antagonist]
18323-44-9
242-209-1
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446598
QJ01FF01
Antiinfectants for systemic use: Antibacterials for systemic use
No
No data
424.98
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(2S,4R)-N-{2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]propyl}-1-methyl-4-propylpyrrolidine-2-carboxamide
methyl-7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio--threo-a-D-galacto-octopyranoside
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Yellow, amorphous solid as parent, white liquid as phosphate
Clindacyl 300 mg tablets
Vetoquinol UK Ltd
UK National authorisation (IC)
Prescription only medicine to be authorised by a veterinarian (POM-V)
Clindacyl 75 mg tablets
Vetoquinol UK Ltd
UK National authorisation (IC)
Prescription only medicine to be authorised by a veterinarian (POM-V)
Antirobe capsules 150mg
Pfizer Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Clinacin 150mg tablets
Chanelle Animal health
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied in tablet or capsule form for oral administration
30.6
Low
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141
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
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Decomposes before boiling
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
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334
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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1.45 X 1002
Calculated
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2.16
Low
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1.29
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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7.02 X 10-12
Low volatility
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Stable
Stable
Hydrolysis not expected under environmental conditions
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Soil adsorption and mobility
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Moderately mobile
360
Estimated
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None
Terrestrial ecotoxicology
1832
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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1832
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
Moderate
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Subcutaneous LD₅₀ = 2618 mg kg⁻¹
Rat
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Excreted mainly in bile with around 20% eliminated in the faeces and urine. Secreted in breast milk.
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause severe intestinal problems including diarrhoea, nausea & colitis
In a fire may decompose and produce irritating vapors and toxic compounds
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Not listed (Not listed)
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clindamycin
clindamycine
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clindamicina
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Record last updated:
30/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242