Lincomycin
Last updated: 31/08/2023
(Also known as: lincomycine; cillimycin; LCM)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
A drug used to treat bacterial infections, skin infections, wound infections, bone infections, pneumonia, dental (tooth) infections and other infections.
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Dogs, Cats, Pigs, Poultry, Cattle, Bees
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C₁₈H₃₄N₂O₆S
CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)O
CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@H](C2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)C(C)O
OJMMVQQUTAEWLP-ZUWRKQLMSA-N
InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11+,12+,13+,14-,15-,16+,18-/m1/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
lincomycin hydrochloride monohydrate
Variant
Antibiotic, Antibacterial, Antimicrobial, Medicinal drug
Lincosamide
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Natural
It inhibits bacteria by suppressing protein synthesis and growth.
[50S ribosomal protein L10, antagonist]
154-21-2
205-824-6
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3000540
QJ01FF02
Antiinfectants for system use: Antibacterials for systemic use
No
Allowed substance (Table 1: All food producing species)
406.54
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(2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide
D-erythro-α-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-
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White crystalline powder
Lincocin Forte S Intramammary Solution
Pfizer Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Lincocin premix 44 g/kg for Medicated Feed
Pfizer Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Lincoject 10 %w/v Solution for Injection
Norbrook Labs
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Linco-Spectin 100 Soluble powder
Pfizer Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Available in a variety of formulations including medicated feeds, intramammary solutions, solutions for injection and soluble powders
927
R4 R = Peer reviewed scientific publications 4 = Verified data
High
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295
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
as the hydrochloride
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1.95 X 1000
Calculated
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0.29
R4 R = Peer reviewed scientific publications 4 = Verified data
Low
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12.9
R4 R = Peer reviewed scientific publications 4 = Verified data
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2.46 X 10-14
R4 R = Peer reviewed scientific publications 4 = Verified data
Low volatility
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Soil adsorption and mobility
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R4 R = Peer reviewed scientific publications 4 = Verified data
Mobile
59
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Known soil and groundwater metabolites
None
lincomycin sulfoxide
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Mammals
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N-desmethyl-lincomycin sulfoxide
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Mammals
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Terrestrial ecotoxicology
> 4000
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat as the hydrochloride
Low
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> 1000
R4 R = Peer reviewed scientific publications 4 = Verified data
Eisenia foetida
Low
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> 980
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Lepomis macrochirus as the hydrochloride
Low
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379.4
R4 R = Peer reviewed scientific publications 4 = Verified data
Daphnia magna
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 4000
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat as the hydrochloride
Low
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Subcutaneous LD₅₀ = 9778 mg kg⁻¹
Rat
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Intramuscular LD₅₀ = 0.2 mg kg⁻¹
Rabbit
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The parent drug and metabolites are excreted mainly in the urine, bile and faeces. Distributed in milk.
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E2 E = Unspecified genotoxicity type (miscellaneous data source) 2 = Mixed/ambiguous results
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause diarrhoea, vomiting and colitis May cause hypotension and, albeit rarely, cardiac arrest
No information available
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Not listed (Not listed)
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lincomycin
lincomycine
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lincomicina
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Record last updated:
31/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242