Halothane |
![]() Last updated: 15/04/2021 |
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(Also known as: fluothane) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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A substance used for inhalational anesthesia | |
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1951, first synthesised | |
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Horses, Domestic animals, Mammals, Birds and Reptiles. |
Chemical structure |
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₂HBrClF₃ | |
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C(C(F)(F)F)(Cl)Br | |
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No data | |
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BCQZXOMGPXTTIC-UHFFFAOYSA-N | |
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InChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H | |
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Yes |
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Common Name | Relationship | Link |
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halothane | - | ![]() |
General status |
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Anesthesetic | |
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Halogenated alkane | |
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Synthetic | |
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Involves interactions with multiple receptor sites to interfere with synaptic transmission. | |
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[Potassium channel subfamily K member 3, binder], [Potassium channel subfamily K member 9, binder], [Calcium-activated potassium channel subunit alpha 1, inhibitor], [Glutamate [NMDA] receptor subunit 3A, inhibitor], [Glutamate [NMDA] receptor subunit 3B, inhibitor], [Glutamate [NMDA] receptor subunit epsilon-1, inhibitor], [Glycine receptor subunit alpha-1, modulator], [Rhodopsin], [G protein-activated inward rectifier potassium channel 2, inhibitor], [G protein-activated inward rectifier potassium channel 1, inhibitor], [NADH-ubiquinone oxidoreductase chain 1, inhibitor], [Intermediate conductance calcium-activated potassium channel protein 4, inhibitor], [ ATP synthase delta chain, mitochondrial], [Calcium-transporting ATPase type 2C member 1], [Gamma-aminobutyric-acid (GABA) receptor subunit alpha-1], [Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit], [Neuropeptide S receptor] | |
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151-67-7 | |
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205-796-5 | |
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QN01AB01 | |
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Nervous system: Anaesthetics | |
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No | |
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No data | |
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197.38 | |
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2-bromo-2-chloro-1,1,1-trifluoroethane | |
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1,1,1-trifluoro-2-bromo-2-chloroethane | |
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Colourless volatile liquid |
Formulations |
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Halothane-Vet 100% Inhalation vapour, liquid | Merial Animal Health Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Usually supplied as a liquid from which vapours are inhaled |
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4070 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
High | ||||||||
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-118 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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50.2 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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2.00 X 1002 | Calculated | - | |||||||
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2.3 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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1.87 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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4.02 X 1007 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Highly volatile | ||||||||
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Degradation |
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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bromide | - | Humans (Liver) | - | Cytochrome P450 2E1 (Some involvement of CYP3A4 & CYP2A6) | |||||
trifluoroacetic acid | - | Humans (Liver) | - | Cytochrome P450 2E1 (Some involvement of CYP3A4 & CYP2A6) |
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Terrestrial ecotoxicology |
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> 5680 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 5680 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Low | ||||||||
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29.0 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 129 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Human3 = Unverified data of known source |
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Mainly eliminated via the lungs | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Strong respiratory depressant May cause cardiac arrest, hypotension, respiratory arrest, cardiac arrhythmias, hyperpyrexia, shivering, nausea |
Handling issues |
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Non-flammable, highly volatile | |||
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Not listed (Not listed) | |||
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halothane | ||
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halotano | ||
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Record last updated: | 15/04/2021 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |