Detomidine
Last updated: 24/06/2022
(Also known as: domosedan)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Used, normally as the hydrochloride, as a large animal sedative, primarily used in horses and large animals
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Horses, Large animals
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C₁₂H₁₄N₂
CC1=C(C(=CC=C1)CC2=CN=CN2)C
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RHDJRPPFURBGLQ-UHFFFAOYSA-N
InChI=1S/C12H14N2/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12/h3-5,7-8H,6H2,1-2H3,(H,13,14)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
Detomidine hydrochloride monohydrate
Variant
Anesthetic, Sedative
Imidazole
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Synthetic
An alpha2-adrenergic agonist that induces the sedative effect
[Alpha-2A adrenergic receptor, agonist]
76631-46-4
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QN05CM90
Nervous system: Sedatives and analgesics
No
Allowed substance (Table 1: Bovine, Equidae)
186.26
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4-[(2,3-dimethylphenyl)methyl]-3H-imidazole
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White crystalline
Detogesic 10mg/ml Solution for Injection for Horses
Vetcare Ltd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Equidor 10mg/ml Solution for injection for horses
Vetcare Ltd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Domosedan GEL 7.6 mg/ml oromucosal gel
Orion Corporation
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Equimidine 10mg/ml Solution for Injection for Horses
Provivo Oy
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied as solution for injection
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114
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
> 60
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat as the hydrochloride
High
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 60
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat as the hydrochloride
High
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Primarily eliminated via the urine
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
May have cardiac and respiratory effects
No information available
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Not listed (Not listed)
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detomidine
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detomidina
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Record last updated:
24/06/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242