Thiamazole
Last updated: 20/08/2023
(Also known as: methimazole; tapazole; dibazol; methylmercaptoimidazole )
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A drug used for the stabilisation and treatment of hyperthyroidism in cats. A chemical degradation product of carbimazole.
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Cats
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C₄H₆N₂S
CN1C=CNC1=S
No data
PMRYVIKBURPHAH-UHFFFAOYSA-N
InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
thiamazole
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Antithyroid drug, Medicinal drug
Human, Animal
Thioamide
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Synthetic
Inhibits the addition of iodine to thyroglobulin by the enzyme thyroperoxidase
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60-56-0
200-482-4
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QH03BB02
Thyroid therapy
No
No data
114.17
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1-methyl-3H-imidazole-2-thione
1-methyl-1,3-dihydroimidazole-2-thione
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Beige coloured, odourous powder
Felimazole 2.5mg Coated Tablets for Cats
Dechra Ltd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Felimazole 5mg Coated Tablets for Cats
Dechra Ltd
Prescription only medicine to be authorised by a veterinarian (POM-V)
EU Mutually recognised procedure
Usually supplied in tablet form for oral administration
2.75
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Low
8000
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Ether
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220000
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Chloroform
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200000
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Methanol
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146
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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155
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
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280
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
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47
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
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5.01 X 10-01
Calculated
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-0.3
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Low
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1.36
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
glucuronide
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Animals (Urine)
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Terrestrial ecotoxicology
> 2250
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 2250
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
Low
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Subcutaneous LD₅₀ = 1050 mg kg⁻¹
Rat
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Intraperitoneal LD₅₀ = 500 mg kg⁻¹
Mouse
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Some metabolism, parent and metabolites excreted in urine and faeces
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
✓Yes, known to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause joint and muscle pain, drowsiness or dizziness Possible blood, liver, endocrine and thyroid toxicant
Slightly flammable Emits toxic fumes of nitroxides and sulfoxides in a fire Risk of dust explosion
Health: H302, H317, H319, H361
Not listed (Not listed)
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thiamazole
thiamazol
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tiamazol
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Record last updated:
20/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242