Omeprazole
Last updated: 23/04/2021
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Drug used for treating acid-induced inflammation and ulcers of the stomach and duodenum and to prevent gastric bleeding. The drug also has some antibiotic action and may be used to treat stomach infectons.
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1989, first marketed
Horses
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C₁₇H₁₉N₃₀₃S
CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC
No data
SUBDBMMJDZJVOS-UHFFFAOYSA-N
InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
omeprazole
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Medicinal drug, Antibiotic
Unclassified substance
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Synthetic
Selective and irreversible proton pump inhibitor, inhibits gastric acid secretion
[Potassium-transporting ATPase alpha chain 1, antagonist]
73590-58-6
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QA02BC01
Alimentary tract & metabolism: Drugs for acid related disorders
No
Allowed substance (Table 1: Equidae)
345.42
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(RS)-6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl) methylsulfinyl)-1H-benzo[d]imidazole
5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
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White powder
Gastrogard 37% w/w oral paste for Horses
Merial Animal Health
EU Mutually recognised procedure
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Usually supplied as an oral paste
82.3
Moderate
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156
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1.58 X 1002
Calculated
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2.2
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Low
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1.22 X 10-07
Low volatility
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
omeproazole sulfone
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Human (Liver)
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Cytochrome P450 3A4
omeprazole sulfide
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Human (Liver)
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Cytochrome P450 3A4
5-hydroxyomeprazole
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Human (Liver)
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Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 2C19
5-O-desmethylomeprazole
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Human (Liver)
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Cytochrome P450 2C19
Terrestrial ecotoxicology
> 2210
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 2210
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Low
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Subcutaneous LD₅₀ > 100 mg kg⁻¹
Rat
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Intraperitoneal LD₅₀ > 100 mg kg⁻¹
Rat
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Metabolised in the liver with ~80% being excreted as metabolites in the urine, remainder is lost in faeces and bile.
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E2 E = Unspecified genotoxicity type (miscellaneous data source) 2 = Mixed/ambiguous results
No
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
XNo, known not to cause a problem
?Possibly, status not identified
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause headache, diarrhoea, abdominal pain, nausea and dizziness May increase risk of hip fracture
Hygroscopic and photosensitive
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Not listed (Not listed)
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omeprazole
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omeprazol
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Record last updated:
23/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242