Toceranib
Last updated: 26/04/2021
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A dog specific anti-cancer drug used in the treatment of canine mast cell tumor called mastocytoma
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2010
Dogs
Isomeric
C₂₂H₂₅FN₄O₂
CC1=C(NC(=C1C(=O)NCCN2CCCC2)C)C=C3C4=C(C=CC(=C4)F)NC3=O
CC1=C(NC(=C1C(=O)NCCN2CCCC2)C)/C=C\3/C4=C(C=CC(=C4)F)NC3=O
SRSGVKWWVXWSJT-ATVHPVEESA-N
InChI=1S/C22H25FN4O2/c1-13-19(12-17-16-11-15(23)5-6-18(16)26-21(17)28)25-14(2)20(13)22(29)24-7-10-27-8-3-4-9-27/h5-6,11-12,25H,3-4,7-10H2,1-2H3,(H,24,29)(H,26,28)/b17-12-
Yes
Anti-cancer agent, Medicinal drug
Unclassified substance
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Synthetic
A receptor tyrosine kinase inhibitor
[c-KIT protein, antagonist], [Vascular endothelial growth factor receptor-2 (VEGFR-2), antagonist], [Platelet-derived growth factor receptor (PDGFR-beta), antagonist]
356068-94-5
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QL01XE91
Antineoplastic & immunomodulating agents: Antineoplastic agents
No
No data
396.46
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(Z)-5-[(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide
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Palladia 10mg Film-coated tablets for dogs
Pfizer Ltd
EU Centralised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Palladia 15mg Film-coated tablets for dogs
Pfizer Ltd
EU Centralised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Palladia 50mg Film-coated tablets for dogs
Pfizer Ltd
EU Centralised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied in tablet form for oral administration
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
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HUMAN HEALTH AND PROTECTION
High (class III)
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Predominatly eliminated in the faeces
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
No data found
No data found
 
May cause lack of appetite, vomiting and diarrhoea
No information available
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Not listed (Not listed)
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toceranib
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Record last updated:
26/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242