Doxycycline
Last updated: 16/03/2023
(Also known as: vibramycin-D; doxytetracycline)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
An antibiotic drug effective against a broad range of Gram-positive and Gram-negative bacteria and used to treat bacterial infections including pneumonia and other respiratory tract infections
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early 1960s, developed
Dogs, Cats, Pigs, Chickens, Birds
Isomeric
₂₂H₂₄N₂O₈
CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O
C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O
JBIWCJUYHHGXTC-AKNGSSGZSA-N
InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31)/t7-,10+,14+,15-,17-,22-/m0/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
Doxycycline monohydrate
Variant
Antibiotic, Antiparasitic, Antiprotozoal, Antibacterial, Medicinal drug
Tetracycline
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Synthetic
A protein synthesis inhibitor
[30S ribosomal protein S9, antagonist], [30S ribosomal protein S4, antagonist], [16S rRNA, antagonist]
564-25-0
209-271-1
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QJ01AA02
Antiinfectants for systemic use: Antibacterials for systemic use
No
Allowed substance (Table 1: Bovine, Porcine, Poultry)
444.44
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(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)- 3,5,10,12,12a-pentahydroxy- 6-methyl- 1,11-dioxo- 1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide
α-6-deoxy-5-hydroxytetracycline
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Yellow crystalline powder
Doxyseptin 300mg film-coated tablets
Vetoquinol UK Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Karidox 100 mg/ml oral solution for use in drinking water for chickens and pigs
Laboratrorios Karizoo S.A.
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Pulmodox 100 mg/g premix for medicated feeding stuff for pigs
Lavet Pharmaceuticals Ltd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Ronaxan 20mg Tablets
Merial Animal health Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Available in a variety of formulations including tablets and medicated feeds
630
High
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201
Chars without melting
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9.55 X 10-01
Calculated
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-0.02
Low
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1.89 X 10-18
Low volatility
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Max in 0.01 N Methanolic hydrogen chloride: 267nm LOG E= 4.24, 351nm LOG E= 4.12
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
> 2000
Rat
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 2000
Rat
Low
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Intravenous LD₅₀ = 228 mg kg⁻¹
Rat
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Intraperitoneal LD₅₀ = 378 mg kg⁻¹
rat
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Largely metabolised and excreted in the faeces (20-40%) and urine (20-30%)
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E1 E = Unspecified genotoxicity type (miscellaneous data source) 1 = Positive
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
✓Yes, known to cause a problem
 
May cause photosensitivity skin reactions May cause nausea and vomiting
No information available
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Not listed (Not listed)
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doxycycline
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doxiciclina
doxiciclina
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Record last updated:
16/03/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242