Tilmicosin |
![]() Last updated: 31/08/2023 |
![]() |
(Also known as: 20-deoxy-20-(3,5-dimethylpiperidin-1-yl)-desmycosin ; AH0230 / AH0470; tilmicosina) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
---|---|---|
![]() Significant data are missing |
![]() Significant data are missing |
|
![]() |
|
A macrolide antibiotic recommended for treatment and prevention of pneumonia associated with Pasteurella haemolytica, P. multocida, Actinobacillus pleuropneumoniae, mycoplasma species and other microorganisms | |
---|---|---|
|
- | |
|
- | |
|
Cattle, Sheep, Pigs, Poultry, Rabbits, Fish |
Chemical structure |
|
Isomeric | |
---|---|---|
|
C₄₆H₈₀N₂O₁₃ | |
|
CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)O)N(C)C)O)CCN3CC(CC(C3)C)C)C)C)COC4C(C(C(C(O4)C)O)OC)OC | |
|
CC[C@@H]1[C@H](/C=C(/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H](C(CC(=O)O1)O)C)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O)N(C)C)O)CCN3CC(CC(C3)C)C)C)\C)CO[C@H]4[C@@H]([C@@H]([C@@H]([C@H](O4)C)O)OC)OC | |
|
JTSDBFGMPLKDCD-SWSPHLSKSA-N | |
|
InChI=1S/C46H80N2O13/c1-13-36-33(24-57-46-44(56-12)43(55-11)40(53)31(8)59-46)19-25(2)14-15-34(49)28(5)20-32(16-17-48-22-26(3)18-27(4)23-48)42(29(6)35(50)21-37(51)60-36)61-45-41(54)38(47(9)10)39(52)30(7)58-45/h14-15,19,26-33,35-36,38-46,50,52-54H,13,16-18,20-24H2,1-12H3/b15-14+,25-19+/t26-,27+,28-,29+,30-,31-,32+,33-,35-,36-,38+,39-,40-,41-,42-,43-,44-,45+,46-/m1/s1 | |
|
Yes |
General status |
|
Antibiotic, Antibacterial, Antimicrobial, Medicinal drug | |
---|---|---|
|
Macrolide | |
|
- | |
|
- | |
|
Synthetic | |
|
Interferes with protein synthesis | |
|
[50S rRNA, antagonist] | |
|
108050-54-0 | |
|
- | |
|
- | |
|
- | |
|
5282521 | |
|
QJ01FA91 | |
|
Antiinfectants for systemic use: Antibacterials for systemic use | |
|
No | |
|
Allowed substance (Table 1: All food producing species) | |
|
869.15 | |
|
- | |
|
(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4S,5S,6R)-4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-7-[2-[(3R,5S)-3,5-dimethylpiperidin-1-yl]ethyl]-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-1-oxacyclohexadeca-11,13-diene-2,10-dione | |
|
4A-O-de(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-20-deoxy-20-(3,5-dimethyl-1-piperidinyl)-(20(cis: trans)) tylosin | |
|
- | |
|
- | |
|
- | |
|
Formulations |
|
|
|
|
|
||||||
---|---|---|---|---|---|---|---|---|---|---|
|
Hymatil 300 mg/ml solution for injection for cattle | Industrial Veterinaria, S.A., Spain | EU Mutually recognised procedure | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Micotil 300 mg/ml solution for injection | Eli Lilly & Co Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Tilmovet 100mg/g Granules for pigs | Huvepharma N.V. | EU Mutually recognised procedure | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Tilmovet 40g/kg Premix for medicated Feedingstuff for Pigs | Huvepharma N.V. | EU Mutually recognised procedure | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
|
Supplied in both injectable and pre-mix formulations |
|
![]() |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
566000 | R4 R = Peer reviewed scientific publications 4 = Verified data |
High | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
1.23 X 1005 | Calculated | - | |||||||
|
5.09 | R4 R = Peer reviewed scientific publications 4 = Verified data |
High | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
13.16 | R4 R = Peer reviewed scientific publications 4 = Verified data |
- | ||||||||
- | |||||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
UV max: 283nm = 22643 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
- | ||||||||
|
- | - | - | ||||||||
|
- | - | - |
Degradation |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
|
64 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Moderately persistent | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
Literature variable & sparse (i) 45.9% decline in loam soil after 1 year, no decline in clay loam after 1 year (E3); (ii) >64 days (R3) | ||||||||||
|
- | - | - | ||||||||
|
|
0.82 | E4 E = Manufacturers safety data sheets 4 = Verified data |
Fast | |||||||
|
Not pH sensitive | ||||||||||
|
|
Stable | E4 E = Manufacturers safety data sheets 4 = Verified data |
Stable | |||||||
|
Stable at pH 5 & 7, DT₅₀ 156 days at pH 9 | ||||||||||
|
- | - | - | ||||||||
|
- | - | - |
Soil adsorption and mobility |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
|
210 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
Slightly mobile | |||||||
|
2800 | ||||||||||
|
Kd range 129-318 mL g⁻¹; Other data: 2800 mL g⁻¹ Estimated (CA2) | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
- | ||||||||||
|
- | ||||||||||
|
- |
Fate indices |
|
|
|
|
||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
1.00 | Calculated | Low leachability | ||||||||||||||||||||||||||
|
|
450 | V1 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Estimated1 = Estimated data with little or no verification |
Threshold for concern | |||||||||||||||||||||||||
|
Not available | - |
Known soil and groundwater metabolites |
None
Other known metabolites |
|
|
|
|
|
|||||
---|---|---|---|---|---|---|---|---|---|
tilmicosin sulphate | - | Rat | - | - | |||||
N-desmethyl tilmicosin | - | Animal | - | - |
|
![]() |
Terrestrial ecotoxicology |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
> 800 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
|
|
- | - | - | |||||||
|
- | - | |||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
> 4710 mg kg feed⁻¹ | E4 E = Manufacturers safety data sheets Anas platyrhynchos4 = Verified data |
- | ||||||||
|
- | - | - | ||||||||
|
> 918 | E3 E = Manufacturers safety data sheets Eisenia foetida 28 day3 = Unverified data of known source |
Moderate | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
- | - | - | |||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
- | |||||||||||
|
- | - | - | ||||||||
- | |||||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - |
Aquatic ecotoxicology |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
851 | E4 E = Manufacturers safety data sheets Oncorhynchus mykiss4 = Verified data |
Low | ||||||||
|
- | - | - | ||||||||
|
57.3 | E4 E = Manufacturers safety data sheets Daphnia magna4 = Verified data |
Moderate | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
0.35 | E4 E = Manufacturers safety data sheets Selenastrum capricornutum growth4 = Verified data |
Moderate | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - |
|
- | - | - |
|
![]() |
General |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
High (class III) | - | - | ||||||||
|
> 800 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | |||||||||
|
- | ||||||||||
|
Very little metabolism, excreted unchanged predominately in the faeces | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
- |
Health issues |
|
|
||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Severe allergen Cardiovascular toxicant |
Handling issues |
|
|
|||
---|---|---|---|---|
|
May emit toxic fumes when heated to decomposition | |||
|
- | |||
|
Not listed (Not listed) | |||
|
- | |||
|
- | |||
|
- |
|
![]() |
|
|
||
---|---|---|---|
|
tilmicosin | ||
|
tilmicosine | ||
|
- | ||
|
- | ||
|
- | ||
|
tilmicosina | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
- |
Record last updated: | 31/08/2023 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |