Gentamicin
Last updated: 29/03/2022
(Also known as: gentacycol; gentamycinum; gentamycin; crop antibiotic)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Drug used to treat a range of Gram-negative bacterial infections
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1963, first isolated
Cats, Dogs, Horses
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C₂₁H₄₃N₅O₇
CC(C1CCC(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)NC
No data
CEAZRRDELHUEMR-UHFFFAOYSA-N
InChI=1S/C21H43N5O7/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20/h9-20,25-29H,5-8,22-24H2,1-4H3
Yes
Antibiotic, Antibacterial, Medicinal drug
Aminoglycoside substance; Micro-organism derived susbstance
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Synthetic
Broad spectrum, inhibits protein synthesis,
[30S ribosomal protein S12, adduct], [16S rRNA, adduct], [Low-density lipoprotein receptor-related protein 2]
1403-66-3
215-765-8
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QA07AA91; QG01AA91; QG51AA04; QJ51GB03
Alimentary tract & metabolism; Genito urinary system & sex hormones; Antiinfectants for systemic use
No
Allowed substance (Table 1: Bovine, Porcine)
477.60
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(3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,6S)-3-amino-6-[(1R)-1-(methylamino)ethyl]oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol
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White to beige coloured, amorphous powder
Clinagel-Vet, gentamicin 0.30% w/w eye gel
Ecuphar n.v./s.a.
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Easotic Ear Drops Suspension for Dogs
Virbac S.A.
EU Centralised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Genta Equine 10% Solution for Injection
Franklin Pharmaceuticals Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Otomax Ear Drops Suspension
Schering-Plough Ltd
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied in either tablet form or as a cream or gel for topical application
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105
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1.32 X 10-02
Calculated
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-1.88
Low
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
> 6600
Rat
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 6600
Rat
Low
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Intravenous LD₅₀ = 96 mg kg⁻¹
Rat
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Intraperitoneal LD₅₀ = 735 mg kg⁻¹
Rat
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No metabolism and excreted unchanged in the urine. Can cross the placenta.
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
XNo, known not to cause a problem
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
May cause anorexia, confusion, depression, disorientation and visual hallucinations May damage hearing Kidney toxicant
When heated to decomposition it emits acrid smoke and fumes
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Not listed (Not listed)
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gentamicin
gentamicine
Gentamycin
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gentamicina
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Record last updated:
29/03/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242