Cloxacillin
Last updated: 08/04/2021
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
An antibiotic drug that is a chlorinated detivative of oxacillin and used to treat many different types of infections caused by staphylococcus bacteria
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Cattle, Dogs, Cats, Horses, Sheep
Isomeric
C₁₉H₁₈ClN₃O₅S
CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O
CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)O
LQOLIRLGBULYKD-JKIFEVAISA-N
InChI=1S/C19H18ClN3O5S/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27)/t13-,14+,17-/m1/s1
Yes
Antibiotic, Antibacterial, Medicinal drug
Isoxazolyl-penicillin
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Semi-synthetic
Interferes with the last stage of bacterial cell wall synthesis
[Penicillin-binding proteins 1A/1B, antagonist], [Beta-lactamase, agonist], [Penicillin-binding protein 2a, antagonist], [Penicillin-binding protein 2B, antagonist], [Penicillin-binding protein 3, antagonist], [Penicillin-binding protein 5, antagonist]
61-72-3
200-514-7
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QJ51CF02; QS01AA90
Antiinfectants for systemic use: Antibacterials for intramammary use; Sensory organs: Ophthalmologicals
No
Allowed substance (Table 1: All food producing species)
435.88
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(2S,5R,6R)-6-{[3-(2-chlorophenyl)-5-methyl-oxazole-4-carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
6-(3-(o-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanic acid
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White crystalline powder
Bovaclox DC Intramammary Suspension
Norbrook Labs
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Kloxerate DC500mg Intramammary Suspension
Pfizer Ltd
UK National authorisation (IC)
Prescription only medicine to be authorised by a veterinarian (POM-V)
Lactaclox Intramammary Infusion
Norbrook Labs
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Sheptaclox DC Intramammary Suspension
Norbrook Labs
UK National authorisation (IC)
Prescription only medicine to be authorised by a veterinarian (POM-V)
Available in a variety of formulations including intramammary suspensions and infusions
13.9
Low
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173
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3.02 X 1002
Calculated
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2.48
Low
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2.78
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
> 5000
Rat as the sodium salt
Low
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23.4
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Green algae
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 5000
Rat as the sodium salt
Low
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Intravenous LDLo = 1680 mg kg⁻¹
Human
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Intracerebral LD₅₀ = 8.1 mg kg⁻¹
Mouse
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Around 50% of administered dose is rapidly (<6hrs) excreted in urine with additional losses via bile and faeces
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
?Possibly, status not identified
No data found
 
May cause diarrhoea and abdominal cramps May cause allergic reaction May cause skin rashes and contact dermatitis
No information available
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None - not a ppp
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cloxacillin
cloxacilline
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cloxacilina
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Record last updated:
08/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242