Delmadinone |
![]() Last updated: 07/09/2025 |
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(Not known by any other names) |
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Delmadinone is a steroid with progestogenic, anti-androgenic and weak glucocorticoid activity | |
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Used for aggressiveness and or nervousness in animals as a form of temporary chemical castration, or as a determinate to whether surgical castration is an option to control aggressive behavior | |
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Dogs; Cats |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Delmadinone exhibits stereoisomerism, specifically diastereomerism, due to the presence of multiple chiral centres in its steroidal structure. The molecule contains several asymmetric carbon atoms, particularly at positions C8, C9, C10, C13, C14, C17, and C20, which allow for different spatial arrangements of substituents. | |
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C₂₁H₂₅ClO₃ | |
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CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(=O)C=CC34C)Cl)C)O | |
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CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C=C(C4=CC(=O)C=C[C@]34C)Cl)C)O | |
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ZSAMZEYLGUEVJW-TTYLFXKOSA-N | |
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InChI=1S/C21H25ClO3/c1-12(23)21(25)9-6-16-14-11-18(22)17-10-13(24)4-7-19(17,2)15(14)5-8-20(16,21)3/h4,7,10-11,14-16,25H,5-6,8-9H2,1-3H3/t14-,15+,16+,19-,20+,21+/m1/s1 | |
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General status |
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Hormone therapy, Medicinal drug | |
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Progestogen | |
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Natural | |
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Affects testosterone production by restraining interstitial cell function | |
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15262-77-8 | |
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239-306-6 | |
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Genito urinary system & sex hormones: Progestogens | |
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QG03DX91 | |
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No | |
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360.87 | |
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6-chloro-17α-hydroxy-1,4,6-pregnatrien-3,20-dione | |
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6-chloro-17-hydroxypregna-1,4,6-triene-3,20-dione | |
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Commercial |
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Tardak 10mg/ml Suspension for injection | Pfizer Ltd | Not licensed | Not licensed | ||||||
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The production of delmadinone involves a multi-step organic synthesis rooted in steroid chemistry. The process typically begins with a suitable steroidal precursor, such as 17alpha-hydroxyprogesterone, which undergoes chlorination at the C6 position to introduce a chlorine atom. This is followed by selective dehydrogenation to create double bonds at the C1–C2 and C6–C7 positions, forming the triene structure characteristic of delmadinone. The final step involves acetylation at the 17alpha-hydroxyl group to yield delmadinone acetate, the active pharmaceutical form used in veterinary medicine | |||||||||
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Published GHG data is not available for most pharmaceuticals. However, according to industry, global averages suggest producing 1 kg of a typical active pharmaceutical ingredient can range from 10 to 100 kg CO₂e for small molecule drugs and potentially up to 1000 kg CO₂e for complex biologicals such as vaccines, depending on the drug type, its formulation, complexity of synthesis, solvent recovery, and energy sources used. |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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540 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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General |
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High (class III) | - | - | ||||||||
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540 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Moderate | ||||||||
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Health issues |
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No further information available |
Handling issues |
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Not listed (Not listed) | |||
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delmadinone | ||
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Record last updated: | 07/09/2025 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |