Ramipril (Ref: HOE-498)
Last updated: 26/04/2021
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A prodrug used to treat hypotension and cardiovascular diseases
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Dogs
Isomeric
C₂₃H₃₂N₂O₅
CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C3CCCC3CC2C(=O)O
CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCC[C@H]3C[C@H]2C(=O)O
HDACQVRGBOVJII-JBDAPHQKSA-N
InChI=1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
ramipril
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Antihypertensive agent, Medicinal drug
Unclassified substance
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Synthetic
An angiotensin-converting enzyme (ACE) inhibitor
[Angiotensin-converting enzyme, antagonist]
87333-19-5
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QC09AA05
Alimentary tract & metabolism: Agents working on the renin-antiotensin system
No
No data
416.51
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(2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid
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White solid
Vasotop 0.625 mg tablets
Intervet UK Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Vasotop 10 mg tablets
Intervet UK Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Vasotop 5 mg tablets
Intervet UK Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied in tablet form for oral administration
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107
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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2.57 X 1003
Calculated
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3.41
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
High
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1.2
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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3.17
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
ramiprilat Note: Pharmacologically active
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Terrestrial ecotoxicology
> 10000
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 10000
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Low
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Intravenous LD₅₀ = 600 mg kg⁻¹
Rat
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Mostly excreted as the active metabolite by the kidneys
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
XNo, known not to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
No data found
No data found
Eye irritant
Phototoxicant
 
No data found
No data found
 
No further information available
Emits toxic fumes under fire conditions
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Not listed (Not listed)
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ramipril
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Record last updated:
26/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242