Cimetidine
Last updated: 30/08/2023
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
A drug used for the treatment and prevention of stomach and intestinal ulcers
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1976, UK approval
Dogs
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C₁₀H₁₆N₆S
CC1=C(N=CN1)CSCCNC(=NC)NC#N
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AQIXAKUUQRKLND-UHFFFAOYSA-N
InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
cimetidine
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Gastrointestinal agent, Histamine antagonists, Medicinal drug
Imidazole
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Synthetic
Acts by inhibiting gastric acid secretion, as well as pepsin and gastrins output.
[Histamine H2 receptor, antagonist]
51481-61-9
257-232-2
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2756
QA02BA01
Alimentary tract & metabolism: Drugs for acid related disorders
No
No data
252.34
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2-cyano-1-methyl- 3-(2-[(5-methyl- 1H-imidazol- 4-yl)methylthio]ethyl)guanidine
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Crystalline white powder
Zitac vet 100 mg tablet for dogs
Intervet International BV
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Zitac vet 200 mg tablet for dogs
Intervet International BV
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied in tablet form for oral administration
9380
High
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142
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Decomposes before boiling
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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2.51 X 1000
Calculated
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0.40
R4 R = Peer reviewed scientific publications 4 = Verified data
Low
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6.8
R4 R = Peer reviewed scientific publications 4 = Verified data
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Stable
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Stable
Chemically stable in water
4
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Non-persistent
DT₅₀ 2 to 200 hours Lake water
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
cimetidine sulfoxide
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Human (Urine)
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5-hydroxymethyl-cimetidine
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Human (Urine)
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Terrestrial ecotoxicology
2550
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Mouse
Low
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> 100
R4 R = Peer reviewed scientific publications 4 = Verified data
Oryzias latipes
Low
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379.7
R4 R = Peer reviewed scientific publications 4 = Verified data
Daphnia magna
Low
230
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Daphnia magna
Low
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> 105
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Selenastrum capricornutum IC50
Low
105
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Selenastrum capricornutum
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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2550
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Mouse
Low
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Subcutaneous LD₅₀ = 860 mg kg⁻¹
Rat
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Intravenous LD₅₀ = 106 mg kg⁻¹
Rat
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About 50% to 80% of an intravenous dose is excreted as unchanged drug in the urine
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause gastrointestinal problems Possible renal toxicant May cause hypotension and bradycardia IARC Group 3 carcinogen - not classifiable
No information available
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Not listed (Not listed)
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cimetidine
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cimetidina
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Record last updated:
30/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242