Nimesulide
Last updated: 21/06/2023
(Also known as: emsulide; rebsulide; methanesulphonamide)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties and used to reduce inflammation and pain associated with musculo-skeletal disorders
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1985, launched
Dogs
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C₁₃H₁₂N₂O₅S
CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2
No data
HYWYRSMBCFDLJT-UHFFFAOYSA-N
InChI=1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
nimesulide
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Analgesic, Anti-inflammatory, Medicinal drug
Unclassified substance
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Synthetic
Selective, orally active cyclooxygenase-2 (COX-2) inhibitor.
[Prostaglandin G/H synthase 2, inhibitor], [Group IIE secretory phospholipase A2], [Lactotransferrin]
51803-78-2
257-431-4
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QM01AX17
Musculo-skeletal system: Antiinflammatory & antirheumatic products
No
No data
308.31
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N-(4-nitro-2-phenoxyphenyl)methanesulfonamide
4-nitro-2-phenoxy-methanesulfonanilide
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Yellow to tan coloured crystalline powder
Zolan 100mg Tablets for Dogs
Virbac S.A.
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Zolan 50mg Tablets for Dogs
Virbac S.A.
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied in tablet form for oral administration
26.9
Low
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143
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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3.98 X 1002
Calculated
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2.6
Low
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
4-hydroxynimesulide Note: Pharmacologically active
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Terrestrial ecotoxicology
200
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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200
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Moderate
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Intraperitoneal LD₅₀ = 163 mg kg⁻¹
Rat
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Excreted in the urine (50-65%) and the urine (20-40%) as both unchanged parent and metabolites
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
?Possibly, status not identified
No data found
 
Liver toxicant May cause gastrointestinal problems
IMDG Transport Hazard Class 6.1
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Not listed (Not listed)
UN2811
Packaging Group III (minor danger)
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nimesulide
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nimesulida
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Record last updated:
21/06/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242