Procaine hydrochoride
Last updated: 21/06/2023
(Also known as: novacaine; procaine HCl; aminocaine; chlorocaine)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
A drug used as a local anaesthetic for minor surgical procedures on a variety of animals
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1905, first synthesised
Cattle, Sheep, Goats, Horses, Pigs, Dogs, Cats
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C₁₃H₃₀N₂O₂Cl
CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.Cl
No data
HCBIBCJNVBAKAB-UHFFFAOYSA-N
InChI=1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
Procaine
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Anesthetic, Medicinal drug
Aminobenzoate
99&
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Synthetic
Acts as a sodium channel blocker
[Sodium channel protein type 10 subunit alpha, antagonist], [Glutamate [NMDA] receptor subunit 3A, antagonist], [5-hydroxytryptamine 3 receptor, antagonist], [Sodium-dependent dopamine transporter, antagonist], [Neuronal acetylcholine receptor subunit alpha-2, antagonist]
51-05-8
200-077-2
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QN01BA52
Nervous system: Anaesthetic
No
Allowed susbstance (Table 1: All food producing species)
272.77
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2-(diethylamino)ethyl 4-aminobenzoate hydrochloride
2-(diethylamino) ethyl p-aminobenzoate monohydrochloride
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White, hygroscopic crystalline powder
Adrenacaine Solution for Injection for Cattle
Norbook Labs
EU Mutually recognised procedure
Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Depocillin 300 mg/ml Suspension for Injection
Intervet International BV
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Multiject IMM Intramammary Suspension
Norbook Labs
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Penacare 300 mg/ml Suspension for Injection
Norbook Labs
UK National authorisation (IC)
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied as a solution for subcutaneous injection
68100
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
High
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155
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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195
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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195
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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1.45 X 10-01
Calculated
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-0.84
Low
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8.05
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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1.03 X 10-04
Low volatility
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Max @ 221nm & 290nm for acid
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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1.5611
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Soil adsorption and mobility
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Known soil and groundwater metabolites
None
para-aminobenzoic acid Note: More toxic than parent
PABA
Human (Plasma, hydrolysis)
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diethylaminoethanol Note: More toxic than parent
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Human (Plasma, hydrolysis)
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Terrestrial ecotoxicology
200
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Moderate
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10
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Ptychocheilus spp. 24 hour
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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200
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Moderate
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Subcutaneous LD₅₀ = 597 mg kg⁻¹
Rat
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Intravenous LD₅₀ = 38 mg kg⁻¹
Rat
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Majority is metabolised and the metabolised are rapidly (in minutes) excreted mostly in the urine
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
?Possibly, status not identified
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause cardiac and vasodilation effects May cause serious allergic reactions Harmful if swallowed
When heated to decomposition it emits toxic fumes of nitroxides IMDG Transport Hazard Class 6.1
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Not listed (Not listed)
UN2811
Hygroscopic in air Packaging Group III (minor danger)
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procaine hydrochoride
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Record last updated:
21/06/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242