Diprenorphine
Last updated: 31/08/2023
(Also known as: diprenorfin; revivon; M5050; DPN; [3H]-diprenorphine)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A drug used to reverse the sedation effects of opioids and remobilise animals remobilise animals on the completion of veterinary procedures
-
-
Elephants, Deer, Horses
Isomeric
C₂₆H₃₅NO₄
CC(C)(C1CC23CCC1(C4C25CCN(C3CC6=C5C(=C(C=C6)O)O4)CC7CC7)OC)O
CC(C)([C@H]1C[C@@]23CC[C@@]1([C@H]4[C@@]25CCN([C@@H]3CC6=C5C(=C(C=C6)O)O4)CC7CC7)OC)O
OIJXLIIMXHRJJH-KNLIIKEYSA-N
InChI=1S/C26H35NO4/c1-23(2,29)18-13-24-8-9-26(18,30-3)22-25(24)10-11-27(14-15-4-5-15)19(24)12-16-6-7-17(28)21(31-22)20(16)25/h6-7,15,18-19,22,28-29H,4-5,8-14H2,1-3H3/t18-,19-,22-,24-,25+,26-/m1/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
diprenorphine
-
Remobiliser, Medicinal drug
Unclassified substance
-
-
Synthetic
An opioid antagonist
[Mu-type opioid receptor, antagonist], [Delta-type opioid receptor, antagonist], [Kappa-type opioid receptor, antagonist], [Tripartite motif-containing protein 13]
14357-78-9
238-325-7
-
-
443408
QV03AB92
Various: All other therapeutic products
No
No data
425.56
-
(5α,7α)-17-(cyclopropylmethyl)- 4,5-epoxy- 18,19-dihydro- 3-hydroxy- 6-methoxy-α,α-dimethyl-6,14-ethenomorphinan-7-methanol
21-cyclopropyl-6,7,8,14-tetrahydro-7a-(1-hydroxy-1-methylethyl)-6,14-endo-ethanooripavine; N-(cyclopropylmethyl)-19-methylnororvinol
DEA Controlled susbstance schedule II
-
-
Large Animal Diprevon Solution for Injection
Abbeyvet Export LLP
UK National authorisation (IC)
Prescription only medicine to be authorised by a veterinarian (POM-V)
Large Animal Revivon Solution for Injection
Novartis Animal Health
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Usually supplied as solution for injection
-
-
-
-
-
-
185
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Soil adsorption and mobility
-
-
-
-
-
-
-
-
None
Terrestrial ecotoxicology
316
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat as the hydrochloride
Moderate
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
HUMAN HEALTH AND PROTECTION
High (class III)
-
-
316
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat as the hydrochloride
Moderate
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Metabolised and excreted mainly in the urine
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
-
Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
No data found
No data found
Eye irritant
Phototoxicant
 
No data found
No data found
 
No further information available
No information available
-
Not listed (Not listed)
-
-
-
diprenorphine
-
-
-
-
diprenorfina
-
-
-
-
-
-
Record last updated:
31/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242