Oleandomycin
Last updated: 31/08/2023
(Also known as: amimycin ; matromycin; landomycin; PA-105)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Antibiotic drug produced by Streptomyces antibioticus
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1954, first described
Pigs, Poultry, Cattle
Isomeric
C₃₅H₆₁NO₁₂
CC1CC(C(C(O1)OC2C(CC3(CO3)C(=O)C(C(C(C(OC(=O)C(C(C2C)OC4CC(C(C(O4)C)O)OC)C)C)C)O)C)C)O)N(C)C
C[C@H]1C[C@]2(CO2)C(=O)[C@@H]([C@H]([C@H]([C@H](OC(=O)[C@@H]([C@H]([C@@H]([C@H]1OC3C(C(CC(O3)C)N(C)C)O)C)OC4CC(C(C(O4)C)O)OC)C)C)C)O)C
RZPAKFUAFGMUPI-UQXMPEMXSA-N
InChI=1S/C35H61NO12/c1-16-14-35(15-43-35)32(40)19(4)27(37)18(3)22(7)46-33(41)21(6)31(47-26-13-25(42-11)28(38)23(8)45-26)20(5)30(16)48-34-29(39)24(36(9)10)12-17(2)44-34/h16-31,34,37-39H,12-15H2,1-11H3/t16-,17+,18-,19+,20+,21+,22+,23-,24-,25-,26-,27-,28-,29+,30-,31-,34-,35-/m0/s1
Yes
Antibiotic, Antibacterial, Antimicrobial, Medicinal drug, Feed additive, growth Promotor
Macrolide
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Natural
Interferes with protein synthesis
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3922-90-5
223-495-7
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5284598
QJ01FA05
Antiinfectants for systemic use: Antibacterials for system use
No
No data
687.86
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(3S,5S,6S,7R,8S,9R,12R,13R,14S,15R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-8-[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-5,7,9,12,13,15-hexamethyl-1,11-dioxaspiro[2.13]hexadecane-10,16-dione
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Evidence of use in third world countries
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White amorphous powder
None identified
None identified
No UK authorisation for use with animals
Not applicable
Usually supplied as a feed additive
15.5
at 25 °C
Low
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4.90 X 1001
Calculated
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1.69
Low
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8.5
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
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4.53 X 10-20
Low volatility
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Methanol: 286-289nm
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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23
R4 R = Peer reviewed scientific publications 4 = Verified data
Non-persistent
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Soil adsorption and mobility
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Low risk
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Based on LogP < 3
Low risk
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None
Terrestrial ecotoxicology
> 6700
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 6700
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Low
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Subcutaneous LD₅₀ > 10000 mg kg⁻¹
Rat
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Intravenous LD₅₀ = 440 mg kg⁻¹
Rat
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Excreted mainly in the bile
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
XNo, known not to cause a problem
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
May cause hyposensitivity May cause gastrointestinal problems
When heated to decomposition emits toxic vapors of NOx
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Not listed (Not listed)
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oleandomycin
oleandomycine
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oleandomicina
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Record last updated:
31/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242