Methylprednisolone
Last updated: 21/04/2021
(Also known as: methyleneprednisolone)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A potent anti-inflammatory steroid used to manage inflammatory and allergic conditions such as respiratory diseases and urogenital infections
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Dogs, Cats, Cattle, Horses
Isomeric
C₂₂H₃₀O₅
CC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O
C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O
VHRSUDSXCMQTMA-PJHHCJLFSA-N
InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
methylprednisolone
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Anti-inflammatory, Medicinal drug
Corticosteroid
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Synthetic
Suppresses immune system activity
[Glucocorticoid receptor, agonist]
83-43-2
201-476-4
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QH02AB04
Systemic Hormonal Preparations, Excl. Sex Hormones & Insulins: Corticosteroids for systemic use
No
Allowed substance (Table 1: Bovine)
374.47
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(1S,2R,8S,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
(6α, 11β)-11,17,21-trihydroxy-6-methyl-pregna-1,4-diene-3,20-dione
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White crystalline powder
Depo-Medrone V 40mg/ml Suspension for Injection
Pfizer Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Medrone V Tablets 2mg
Pfizer Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Medrone V Tablets 4mg
Pfizer Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Soul-medrone V 125mg
Pfizer Ltd
UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Available in a variety of formulations including solutions for injection, tablets and ointments for topical application
120
Moderate
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233
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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6.31 X 1001
Calculated
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1.8
Low
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Soil adsorption and mobility
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Low risk
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Based on LogP < 3
Low risk
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Known soil and groundwater metabolites
None
methylprednisolone-17-propionate
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Human
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Cytochrome P450 3A4
hydroxymethylprednisolone
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Human (Liver)
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Cytochrome P450 3A4
Terrestrial ecotoxicology
> 2000
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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> 2000
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
Low
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Intraperitoneal LD₅₀ = 1000 mg kg⁻¹
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
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Subcutaneous LD₅₀ > 3000 mg kg⁻¹
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
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0.00016
Rat
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Metabolised primarily by the liver and excreted by the kidneys. Small amounts of unmetabolized drug are excreted in urine and bile.
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
?Possibly, status not identified
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
XNo, known not to cause a problem
?Possibly, status not identified
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
May induce changes in metabolism May cause glaucoma, osteoporosis and psychosis May cause gastrointestinal problems
No information available
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Not listed (Not listed)
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methylprednisolone
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metilprednisolona
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Record last updated:
21/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242