(Also known as: D1-dehydrohydrocortisone; hydroretrocortine; meticortelone)
Data alerts
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
Environmental fate Moderate alert: Drainflow: Moderately mobile
Human health High alert: Reproduction/development effects
Warning: Significant data are missing
GENERAL INFORMATION
Description
Used for the control of inflammatory and allergic conditions such as asthma, rheumatoid arthritis and colitis and as an immunosuppressive drug for organ transplants
In dairy cows prednisolone is mainly excreted via milk during milking. In other animals it is metabolised in the liver and excreted in the urine as both metabolites and the unchanged substance
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
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Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
;
B0 B = DNA damage/repair (EFSA database) 0 = No data
;
C0 C = Gene mutation (EFSA database) 0 = No data
;
D0 D = Genome mutation (EFSA database) 0 = No data
;
E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
General human health issues
IARC Group 3 carcinogen - not classifiable May cause fluid retention, acne, constipation, and mood swings Toxic to lungs and mucous membranes Osteoporosis is a possible side effect of long term treatment
Handling issues
Property
Value and interpretation
General
Risk of explosion if present during electrical/static discharge
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242