Colistin sulphate |
![]() Last updated: 31/08/2023 |
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(Also known as: colistin; belcomycin; colistin sulfate; coly-mycin; colimycin sulfate; polymixin E sulphate) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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A broad spectrum antibiotic produced by certain strains of Bacillus polymyxa var. colistinus and effective against most Gram-negative bacteria including poultry coccidiosis | |
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Cattle, Fowl, Pigs, Sheep, Rabbits |
Chemical structure |
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Isomeric | |
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C₅₃H₁₀₂N₁₆O₁₇S | |
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CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O | |
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CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)[C@@H](C)O.OS(=O)(=O)O | |
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VEXVWZFRWNZWJX-NBKAJXASSA-N | |
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InChI=1S/C52H98N16O13.H2O4S/c1-9-29(6)11-10-12-40(71)59-32(13-19-53)47(76)68-42(31(8)70)52(81)64-35(16-22-56)44(73)63-37-18-24-58-51(80)41(30(7)69)67-48(77)36(17-23-57)61-43(72)33(14-20-54)62-49(78)38(25-27(2)3)66-50(79)39(26-28(4)5)65-45(74)34(15-21-55)60-46(37)75;1-5(2,3)4/h27-39,41-42,69-70H,9-26,53-57H2,1-8H3,(H,58,80)(H,59,71)(H,60,75)(H,61,72)(H,62,78)(H,63,73)(H,64,81)(H,65,74)(H,66,79)(H,67,77)(H,68,76);(H2,1,2,3,4)/t29?,30-,31-,32+,33+,34+,35+,36+,37+,38+,39-,41+,42+;/m1./s1 | |
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Yes |
General status |
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Antibiotic, Antibacterial, Antimicrobial, Feed additive | |
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Polymixin mix | |
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Natural | |
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Distrupts the bacterial cell membrane changing its permeability. | |
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[Bacterial outer membrane] | |
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1264-72-8 | |
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215-034-3 | |
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91885449 | |
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QA07AA10 | |
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Alimentary tract & metabolism: Intestinal anti-infectives | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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1267.54 | |
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N-((1S)-3-amino-1-(((1S,2R)-1-(((1S)-3-amino-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)- 12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19- heptazacyclotricos-21-yl)carbamoyl)propyl) carbamoyl)-2-hydroxy-propyl) carbamoyl)propyl)-6-methyl-octanamide sulfuric acid | |
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White crystalline powder |
Formulations |
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Coliplus 2,000,000 IU/ml concentrate | Divasa-Farmavic S.A. | EU Mutually recognised procedure | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Colibird Poultry solution for drinking water | Ceva Animal Health Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Coliscour Oral Solution | Ceva Animal Health Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Available in a variety of formulations including feed additives and solutions for mixing with drinking water |
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5640 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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1537 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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883.5 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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3.98 X 10-03 | Calculated | - | |||||||
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-2.4 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
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12.1 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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1.575 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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Soil adsorption and mobility |
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Fate indices |
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Low risk | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Based on LogP < 35 = Verified data used for regulatory purposes |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 5450 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat as sulphate5 = Verified data used for regulatory purposes |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 5450 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat as sulphate5 = Verified data used for regulatory purposes |
Low | ||||||||
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Subcutaneous LD₅₀ = 72.2 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 10.6 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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0.004 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat SF=2005 = Verified data used for regulatory purposes |
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Poisonous by intraperitoneal and intravenous routes | ||||||||||
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Largely (~80%) excreted via the urine, no significant metabolism | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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May cause respiratory muscle paralysis leading to apnea, respiratory arrest and death Possible kidney toxicant |
Handling issues |
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IMDG Transport Hazard Class 6.1 | |||
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Not listed (Not listed) | |||
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UN2811 | |||
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Packaging Group III (minor danger) | |||
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colistin sulphate | ||
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Colistin sulfat | ||
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Record last updated: | 31/08/2023 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |