Maduramicin |
![]() Last updated: 21/04/2021 |
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(Also known as: CL 259971 ) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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A substance with antiprotazoal activity first isolated from actinomycete and used to treat coccidiosis. | |
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Poultry |
Chemical structure |
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Isomeric | |
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C₄₇H₈₃NO₁₇ | |
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CC1CC(C(OC1C2CC(C(O2)C3(CCC(O3)C4(CCC5(O4)CC(C(C(O5)C(C)C6C(C(C(C(O6)(CC(=O)[O-])O)C)OC)OC)C)O)C)C)OC7CC(C(C(O7)C)OC)OC)(C)O)C.[NH4+] | |
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C[C@H]1C[C@H]([C@@](O[C@@H]1[C@H]2C[C@@H]([C@@H](O2)[C@@]3(CC[C@@H](O3)[C@@]4(CC[C@@]5(O4)C[C@@H]([C@H]([C@H](O5)[C@@H](C)[C@H]6[C@@H]([C@H]([C@@H]([C@](O6)(CC(=O)[O-])O)C)OC)OC)C)O)C)C)O[C@@H]7C[C@@H]([C@H]([C@@H](O7)C)OC)OC)(C)O)C.[NH4+] | |
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WQGJEAMPBSZCIF-HKSLRPGUSA-N | |
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InChI=1S/C47H80O17.H3N/c1-23-18-24(2)45(9,51)61-36(23)31-19-32(58-35-20-30(53-10)40(55-12)28(6)57-35)42(59-31)44(8)15-14-33(60-44)43(7)16-17-46(64-43)21-29(48)25(3)37(62-46)26(4)38-41(56-13)39(54-11)27(5)47(52,63-38)22-34(49)50;/h23-33,35-42,48,51-52H,14-22H2,1-13H3,(H,49,50);1H3/t23-,24+,25+,26+,27-,28-,29-,30-,31+,32-,33+,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46+,47+;/m0./s1 | |
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Yes |
General status |
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Antiprotozoal agent, Medicinal drug, Antibacterial, Antibiotic | |
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Monoglycoside polyether (ionophore) | |
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Natural | |
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Acts by affecting cation transport across the cell membrane, increasing the influx of Ca+, Na+, and K+ in the cell wall thereby causing cell membrane disruption and cell death. | |
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84878-61-5 | |
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QP51AX10 | |
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Antiprotozals: Agents again protozoal diseases | |
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No | |
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Not listed | |
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934.16 | |
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azanium;2-[(2R,3S,4S,5R,6S)-6-[(1R)-1-[(2S,5R,7S,8R,9S)-2-[(2R,5S)-5-[(2R,3S,5R)-3-[(2R,4S,5S,6S)-4,5-dimethoxy-6-methyloxan-2-yl]oxy-5-[(2S,3S,5R,6S)-6-hydroxy-3,5,6-trimethyloxan-2-yl]oxolan-2-yl]-5-methyloxolan-2-yl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]ethyl]-2-hydroxy-4,5-dimethoxy-3-methyloxan-2-yl]acetate | |
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maduramicn ammonium | |
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White solid |
Formulations |
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Cygro 1% premix | Alpharma Canada Corp. | - | - | ||||||
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Usually mixed with feed |
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165 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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2.51 X 1003 | Calculated | - | |||||||
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3.4 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
High | ||||||||
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1.18 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Mo significant absorbance between 290 and 750nm | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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Degradation |
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Literature states rapid degradation in soil. DT₅₀ in chicken excreta measure by antibiotic acivity is about 55 days. | ||||||||||
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55 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Temperature dependent3 = Unverified data of known source |
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 2000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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5.0 | E3 E = Manufacturers safety data sheets Salmo gairdneri3 = Unverified data of known source |
Moderate | ||||||||
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7.5 | E3 E = Manufacturers safety data sheets Daphnia magna3 = Unverified data of known source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 2000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Low | ||||||||
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2000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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Over 90% lost in excreta unchanged | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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Health issues |
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May cause muscle weakness & myonecrosis May cause renal failure Highly toxic |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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maduramicin | ||
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maduramicine | ||
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Kaduramicina | ||
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Record last updated: | 21/04/2021 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |