Milbemycin oxime (Ref: CGA-179246) |
![]() Last updated: 14/09/2023 |
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(Also known as: Milbemycin-A4-oxim ) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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  | ![]() Significant data are missing |
![]() Significant data are missing |
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A broad-spectrum antiparasitic drug producted by the fermentation by Streptomyces hygroscopicus variant aureolacrimosus for the treatment of heartworms, mites, fleas, ticks and nematodes (roundworms, tapeworms, hookworms). | |
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Current | |
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circa 1972 | |
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Dogs; Cats |
Chemical structure |
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Isomeric | |
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C₆₃H₈₈N₂O₁₄ | |
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CCC1C(CCC2(O1)CC3CC(O2)CC=C(CC(C=CC=C4COC5C4(C(C=C(C5=NO)C)C(=O)O3)O)C)C)C.CC1CCC2(CC3CC(O2)CC=C(CC(C=CC=C4COC5C4(C(C=C(C5=NO)C)C(=O)O3)O)C)C)OC1C | |
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CC[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/C[C@H](/C=C/C=C/4\CO[C@H]\5[C@@]4([C@@H](C=C(/C5=N/O)C)C(=O)O3)O)C)\C)C.C[C@H]1CC[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/C[C@H](/C=C/C=C/4\CO[C@H]\5[C@@]4([C@@H](C=C(/C5=N/O)C)C(=O)O3)O)C)\C)O[C@@H]1C | |
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CKVMAPHTVCTEMM-ALPQRHTBSA-N | |
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InChI=1S/C32H45NO7.C31H43NO7/c1-6-27-21(4)12-13-31(40-27)17-25-16-24(39-31)11-10-20(3)14-19(2)8-7-9-23-18-37-29-28(33-36)22(5)15-26(30(34)38-25)32(23,29)35;1-18-7-6-8-23-17-36-28-27(32-35)21(4)14-26(31(23,28)34)29(33)37-25-15-24(10-9-19(2)13-18)39-30(16-25)12-11-20(3)22(5)38-30/h7-10,15,19,21,24-27,29,35-36H,6,11-14,16-18H2,1-5H3;6-9,14,18,20,22,24-26,28,34-35H,10-13,15-17H2,1-5H3/b8-7+,20-10+,23-9+,33-28-;7-6+,19-9+,23-8+,32-27-/t19-,21-,24+,25-,26-,27+,29+,31+,32+;18-,20-,22+,24+,25-,26-,28+,30-,31+/m00/s1 | |
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Yes |
General status |
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Anthelmintic agent; Ectoparasiticide | |
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Micro-organism derived substance | |
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>95% | |
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- | |
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Natural | |
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Opens glutamate sensitive chloride channels in neurons and myocytes of invertebrates, leading to hyperpolarisation of these cells and blocking of signal transfer. | |
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129496-10-2 | |
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QP54AB01 | |
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Antiparasitic products, insecticides and repellents: Milbemycins | |
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No | |
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- | |
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1097.4 | |
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None | |
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mixture of 70% (10E,14E,16E)-(1R,4S,5'S,6R,6'R,8R,13R,20R,24S)-6'-ethyl-24-hydroxy-5',11,13,22-tetramethyl-(3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene)-6-spiro-2'-(tetrahydropyran)-2,21-dione 21-(EZ)-oxime and 30% (10E,14E,16E)-(1R,4S,5'S,6R,6'R,8R,13R,20R,24S)-24-hydroxy-5',6',11,13,22-pentamethyl-(3,7,19-trioxatetracyclo(15.6.1.14,8.020,24)pentacosa-10,14,16,22-tetraene)-6-spiro-2'-(tetrahydropyran)-2,21-dione 21-(EZ)-oxime | |
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(6R,25R)-5-demethoxy-28-deoxy-6,28-epoxy-25-ethyl-5-(hydroxyimino)milbemycin B mixture with (6R,25R)-5-demethoxy-28-deoxy-6,28-epoxy-5-(hydroxyimino)-25-methylmilbemycin B | |
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Crystalline solid |
Formulations |
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Milbactor | Krda d.d. | EU Mutually recognised procedure | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Milbeworm | Alfamed | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Milbemax | Novartis | EU Mutually recognised procedure | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Milprazon | Krka d.d. | EU Mutually recognised procedure | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Max @ 246nm | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 980 | P4 P = Other non-EU, UK or US Governments and Regulators Rat 4 = Verified data |
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Aquatic ecotoxicology |
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0.059 | P4 P = Other non-EU, UK or US Governments and Regulators Cyprinus carpio4 = Verified data |
High | ||||||||
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> 100 | P4 P = Other non-EU, UK or US Governments and Regulators Daphnia magna4 = Verified data |
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General |
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> 980 | P4 P = Other non-EU, UK or US Governments and Regulators Rat 4 = Verified data |
Moderate | ||||||||
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200 | P3 P = Other non-EU, UK or US Governments and Regulators Rat as product3 = Unverified data of known source |
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> 5.0 | P3 P = Other non-EU, UK or US Governments and Regulators Rat 4 hr3 = Unverified data of known source |
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Metabolised in the liver; biliary excretion | - | - |
Health issues |
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Harmful by inhalation and ingestion |
Handling issues |
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Non-corrosive Not expected to auto-ignite; Not highly flammable |
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Health: H302, H332 Environment: H400, H410 |
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Not listed (Not listed) | |||
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None allocated | |||
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milbemycin oxime | ||
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oxime de milbemycine | ||
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Record last updated: | 14/09/2023 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |