Alprazolam
Last updated: 30/08/2023
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A veterinary and human drug commonly used to control various anxiety disorders
Current
circa 1969
Dogs; Cats
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C₁₇H₁₃ClN₄
CC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4
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VREFGVBLTWBCJP-UHFFFAOYSA-N
InChI=1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
alprazolam
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Medicinal drug: Tranquiliser; Sedative
Benzodiazepine
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Synthetic
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[GABA-A receptor (anion channel), Modulator]
28981-97-7
249-349-2
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2118
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308.77
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8-chloro-1-methyl-6-phenyl-4H-(1,2,4)triazolo(4,3-α)(1,4)benzodiazepine
8-chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine
May react with other medications
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Xanax
Pfizer
No UK National authorisation
Prescription only medicine to be authorised by a veterinarian (POM-V)
Alprazolam
Greenstone LLC, New Jersey, USA
No UK National authorisation
No UK National authorisation
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13.1
Low
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1.32 X 1002
Calculated
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2.12
Low
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
770
Mouse
Moderate
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HUMAN HEALTH AND PROTECTION
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770
Mouse
Moderate
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Intraperitoneal LD₅₀ = 380 mg kg⁻¹
Mouse
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Subcutaneous LD₅₀ > 5000 mg kg⁻¹
Mouse
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Hepatic metabolism via cytochrome P450 3A4 with renal excretion
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
XNo, known not to cause a problem
?Possibly, status not identified
Respiratory tract irritant
Skin irritant
Skin sensitiser
XNo, known not to cause a problem
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
?Possibly, status not identified
No data found
 
May cause over sedation and loss of motor control CNS toxicant May cuase over excitment and aggression
No information available
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Not listed (Not listed)
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alprazolam
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Record last updated:
30/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242