Nystatin |
![]() Last updated: 31/08/2023 |
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(Not known by any other names) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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A human and veterinary medicine used to treat fungal infections such as yeasts and moulds. | |
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Current | |
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1950, first isolated from bacteria | |
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Cats; Dogs; Pet birds (budgerigars, lovebirds, finches, parrotlets, and cockatiels) |
Chemical structure |
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No data | |
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C₄₇H₇₅NO₁₇ | |
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CC1C=CC=CCCC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(C(CCC(CC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O | |
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C[C@H]1/C=C/C=C/CC/C=C/C=C/C=C/C=C/C(CC2C(C(C[C@](O2)(CC(C(CCC(CC(CC(CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O | |
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VQOXZBDYSJBXMA-RKEBNKJGSA-N | |
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InChI=1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31?,32?,33?,34?,35?,36?,37?,38?,40?,41-,42+,43+,44-,46+,47+/m0/s1 | |
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Yes |
General status |
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Medicinal drug: Antifungal | |
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Bacterial origin | |
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Natural | |
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Binds to ergosterol, a major component of the fungal cell membrane. As concentrations build pores in the membrane develop leading to K+ leakage, acidification and fungal cell death | |
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[Ergosterol, Binder] | |
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1400-61-9 | |
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215-749-0 | |
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202800 | |
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6433272 | |
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QA07AA02; QD01AA01 | |
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Intestinal Antiinfectives - Antidiarrheals, intestinal antiinflammatory/antiinfective agents; Antifungals for topical use - Antifungals for dermatological use | |
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No | |
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926.09 | |
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(1S,3R,4R,7R,9R,11R,15S,16R,17R,18S,19E,21E, 25E,27E,29E,31E,33R,35S,36R,37S)-33-((3-amino-3,6-dideoxy-β-L-mannopyranosyl)oxy)-1, 3,4,7,9,11,17,37-octahydroxy-15, 16,18-trimethyl-13-oxo-14, 39-dioxabicyclo(33.3.1)nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid | |
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(1S,3R,4R,7R,9R,11R,15S,16R,17R,18S,19E,21E, 25E,27E,29E,31E,33R,35S,36R,37S)-33-((3-amino-3,6-dideoxy-β-L-mannopyranosyl)oxy)-1, 3,4,7,9,11,17,37-octahydroxy-15, 16,18-trimethyl-13-oxo-14, 39-dioxabicyclo(33.3.1)nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid | |
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Formulations |
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Canaural Ear Drops | Dechra Veterinary Products A/S | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Derma-Vet Cream | Med-Pharmex | No UK national authorisation | Not applicable | |||||||
Nystatin Oral Suspension | Akorn, Inc., Illinois USA | No UK national authorisation | Not applicable | |||||||
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360 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Moderate | ||||||||
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160 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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250 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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1.58 X 10-03 | Calculated | - | |||||||
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-2.8 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Degradation |
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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10000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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55.0 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Meleagris gallopavo as NOEL3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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10000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Low | ||||||||
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Intraperitoneal LD₅₀ = 4.4 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Intravenous LD₅₀ = 3.0 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Mainly fecal elimination | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause diarrhoea & abdominal pain Harmful if swallowed in high doses |
Handling issues |
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May be combustible in some formulations Not compatible with strong oxidising agents Will emit toxic fumes if heated to decomposition |
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Not listed (Not listed) | |||
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Not regulated | |||
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nystatin | ||
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nystatine | ||
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Nistatina | ||
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Record last updated: | 31/08/2023 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |