Afoxolaner
Last updated: 18/10/2023
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A substance used to control flea and tick infestations as well as demodicosis and sarcoptic mange
Current
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Dogs
Racemic mixture
C₂₆H₁₇ClF₉N₃O₃
C1C(=NOC1(C2=CC(=CC(=C2)Cl)C(F)(F)F)C(F)(F)F)C3=CC=C(C4=CC=CC=C43)C(=O)NCC(=O)NCC(F)(F)F
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OXDDDHGGRFRLEE-UHFFFAOYSA-N
InChI=1S/C26H17ClF9N3O3/c27-15-8-13(7-14(9-15)25(31,32)33)23(26(34,35)36)10-20(39-42-23)18-5-6-19(17-4-2-1-3-16(17)18)22(41)37-11-21(40)38-12-24(28,29)30/h1-9H,10-12H2,(H,37,41)(H,38,40
Yes
Insecticide; Acaracide; Antiparasitic
Isoxazoline
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Synthetic
Blocks synaptic transfer of choride ions across cell membranes and so distrupts insect nervous system.
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1093861-60-9
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QP53BE01
Ectoparasiticides, including insecticides and repellents
Presciption only
No data
625.88
4-(5-(3-chloro-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl)-N-(2-oxo-2-(2,2,2-trifluoroethylamino)ethyl)naphthalene-1-carboxamide
4-(5-(3-chloro-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl)-N-(2-oxo-2-(2,2,2-trifluoroethylamino)ethyl)naphthalene-1-carboxamide
4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide
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Nexgard
Boehringer Ingelheim Animal Health
EU Mutually recognised procedure
Prescription only medicine to be authorised by a veterinarian (POM-V)
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
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HUMAN HEALTH AND PROTECTION
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
No data found
No data found
Eye irritant
Phototoxicant
 
No data found
No data found
 
No information available
No information available
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Not listed (Not listed)
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afoxolaner
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Record last updated:
18/10/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242