Lotilaner
Last updated: 16/05/2023
(Not known by any other names)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A broad-spectrum antiparasitic active ingredient used in veterinary medicine for dogs against external parasites
Current
2017, first introduced by Novartis
Dogs
None
C₂₀H₁₄Cl₃F₆N₃O₃S
CC1=C(SC(=C1)C2=NOC(C2)(C3=CC(=C(C(=C3)Cl)Cl)Cl)C(F)(F)F)C(=O)NCC(=O)NCC(F)(F)F
CC1=C(SC(=C1)C2=NO[C@@](C2)(C3=CC(=C(C(=C3)Cl)Cl)Cl)C(F)(F)F)C(=O)NCC(=O)NCC(F)(F)F
HDKWFBCPLKNOCK-SFHVURJKSA-N
InChI=1S/C20H14Cl3F6N3O3S/c1-8-2-13(36-16(8)17(34)30-6-14(33)31-7-19(24,25)26)12-5-18(35-32-12,20(27,28)29)9-3-10(21)15(23)11(22)4-9/h2-4H,5-7H2,1H3,(H,30,34)(H,31,33)/t18-/m0/s1
Yes
Antiparasitic
Isoxazoline
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Synthetic
Inhibitor of gamma–aminobutyric acid (GABA)-gated chloride channels
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1369852-71-0
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76959255
QP53BE04
Ectoparasiticides for systemic use, isoxazolines
Prescription only
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596.8
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3-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]thiophene-2-carboxamide
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Credelio chewable tablets for dogs
Elanco
POM-V
Prescription only medicine to be authorised by a veterinarian (POM-V)
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
> 2000
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Low
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HUMAN HEALTH AND PROTECTION
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> 2000
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Low
2000
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
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The major route of elimination is biliary excretion
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
No data found
No data found
Eye irritant
Phototoxicant
 
No data found
No data found
 
No information available
No information available
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Not listed (Not listed)
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lotilaner
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Record last updated:
16/05/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242