Icaridin (Ref: KBR 3023)
Last updated: 17/01/2023
(Also known as: icaradine; picaradin; propidine; autan; hydroethyl isobutyl piperidine carboxylate)
Icaridin is an insect repellant. It has a high aquatic solubility and is volatile. Data is limited regarding its environmental persistence. It has a relatively low mammalian toxicity and a high potential to bioaccumulate. It is is not highly toxic to birds or fish. There are gaps in ecotoxicology and environmental fate data.
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
An insect repellant used for both human and animal applications to control a broad spectrum of insect pests
Current
2001, USA first registered; 1998, first available Europe
Livestock
A molecule with 2 chiral centres
C₁₂H₂₃NO₃
CCC(C)OC(=O)N1CCCCC1CCO
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QLHULAHOXSSASE-UHFFFAOYSA-N
InChI=1S/C12H23NO3/c1-3-10(2)16-12(15)13-8-5-4-6-11(13)7-9-14/h10-11,14H,3-9H2,1-2H3
Yes
Insecticide
Piperidine compound
970 g kg⁻¹
None declared by manufacturer; Chemistry suggests sec-butyl chloroformate & sec-butyl carbonic anhydride
Synthetic
Topically applied, repellent. Odorant receptor. It has been proposed that icaridin may bind to odorant binding protein 1 (AgamOBP1).
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119515-38-7
423-210-8
740
070705
125098
No data found
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-
-
-
229.32
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(RS)-sec-butyl (RS)-2-(2-hydroxyethyl)piperidine-1-carboxylate
1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinecarboxylate
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Colourless, odourless liquid
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Available in a variety of formulations including aerosol sprays, pump sprays and towelette wipes
8200
High
Miscible
Propanol
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Miscible
Ethanol
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-170
Freezing point
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296
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-
-
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375
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1.70 X 1002
Calculated
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2.23
Low
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1.04
Q2 Q = Miscellaneous internet resources 2 = Unverified data of unknown source
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Not applicable
Q4 Q = Miscellaneous internet resources 4 = Verified data
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No dissociation
0.034
Low volatility
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-
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Stable
Stable
Stable under normal environmental conditions
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Soil adsorption and mobility
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Moderately mobile
389
Estimated
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1.8
(whole body)
Low potential
ND
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None
Terrestrial ecotoxicology
2236
Rat
Low
100
Q4 Q = Miscellaneous internet resources 4 = Verified data
Rat
Moderate
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> 5000
Colinus virginianus
Low
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173
Oncorhynchus mykiss
Low
50.1
Oncorhynchus mykiss
Low
100
Q2 Q = Miscellaneous internet resources 2 = Unverified data of unknown source
Daphnia magna
Moderate
103
Daphnia magna
Low
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71.5
Scenedemus subspicatus
Low
54.8
Scenedesmus subspicatus
Low
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HUMAN HEALTH AND PROTECTION
High (class III)
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2236
Rat
Low
5000
Rat
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> 4.36
Rat
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Occupational exposure may occur through inhalation and dermal contact
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
XNo, known not to cause a problem
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
XNo, known not to cause a problem
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
No further information available
Not explosive or oxidising
Not classified: Obsolete
III/O (Slightly hazardous / Obsolete substance)
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icaridin
icaridin
Icaridin
icaridin
icaridin
icaridin
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ikarydyna
icaridin
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Record last updated:
17/01/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242