Oxytetracycline |
![]() Last updated: 20/08/2023 |
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(Also known as: terramycin; oxytracyl; oxytetrin; terramitsin; oxitetracycline; crop antibiotic) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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A highly active broad spectrum antibiotic used to control infection animals diseses and bacterial pathogens | |
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Current | |
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Calves, Non-lactating dairy cattle, Beef, Pigs, Fish, Poultry, Cats, Dogs |
Chemical structure |
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A complex molecule with 6 chiral centres | |
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C₂₂H₂₄N₂O₉ | |
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CC1(C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O)O | |
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C[C@@]1([C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O)O | |
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IWVCMVBTMGNXQD-PXOLEDIWSA-N | |
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InChI=1S/C22H24N2O9/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31)/t12-,13-,14+,17+,21-,22+/m1/s1 | |
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Yes |
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Common Name | Relationship | Link |
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oxytetracycline | - | ![]() |
General status |
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Bactericide, Antimicrobial, Antiseptic | |
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Micro-organism derived substance | |
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Natural | |
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Broad spectrum, protein synthesis inhibitor and binds to the 30S and 50S bacterial ribosomal subunits | |
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[30S ribosomal protein S9, antagonist], [30S ribosomal protein S4, antagonist], [16S rRNA, antagonist] | |
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79-57-2 | |
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2058-46-0 | |
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201-212-8 | |
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316 | |
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006308 | |
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QD06AA03 for topical use; QJ01AA06 for systemic use; Others available | |
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Dermatologicals: Antibiotics and chemotherapeutics for dermatological use; Antiinfectants for systemic use: Antibacterials for systemic use | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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460.44 | |
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(4S,4aR,5S,5aR,6S,12aS)-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide | |
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(4S,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide | |
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Possible groundwater contaminant | |
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Formulations |
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Alamycin LA Injection 300mg/ml | Norbrook Labs | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Engemycin DD Solution for Injection | Intervet International | EU Mutually recognised procedure | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Alamycin Aerosol 3.58% w/w Cutaneous Spray, Solution | Norbrook Laboratories Limited | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Cyclosol LA 200mg/ml Solution for Injection | Eurovet Animal Health B.V. | EU Mutually recognised procedure | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Supplied as a water soluble powder for preparation as injection when used as a veterinary product. For crop protection it is used as a foliar spray |
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Degradation |
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43.8 | R4 R = Peer reviewed scientific publications Aerobic sediment slurry; Other data 79 days slurry4 = Verified data |
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Soil adsorption and mobility |
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Fate indices |
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0.6 | J2 J = Pesticide Action Network database (click here ) Mollusca2 = Unverified data of unknown source |
Low potential | |||||||||||||||||||||||||
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Not available | - |
Known metabolites |
None
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Terrestrial ecotoxicology |
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> 5620 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Anas platyrhynchos as the HCl variant3 = Unverified data of known source |
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1954 | R3 R = Peer reviewed scientific publications as the HCl variant3 = Unverified data of known source |
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100 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) as the HCl variant3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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116 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Oncorhynchus mykiss as the HCl variant3 = Unverified data of known source |
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102 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna as the HCl variant3 = Unverified data of known source |
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46.2 | R3 R = Peer reviewed scientific publications Daphnia magna as the HCl variant3 = Unverified data of known source |
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0.342 | R3 R = Peer reviewed scientific publications Selenastrum capricornutum as the HCl variant3 = Unverified data of known source |
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0.183 | R3 R = Peer reviewed scientific publications Selenastrum capricornutum as the HCl variant3 = Unverified data of known source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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Systemically available oxytetracycline was primarily excreted in the urine and bile | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause hypersensitivity reactions May cause tooth discoloration |
Handling issues |
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No information available | |||
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Health: H302, H312, H317, H332, H360d Environment: H400, H410 |
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Not listed (Not listed) | |||
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oxytetracycline | ||
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oxytetracycline | ||
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Oxytetracyclin | ||
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oxytetracyclin | ||
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oxytetracicline | ||
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oxitetraciclina | ||
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oksytetracyklina | ||
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Record last updated: | 20/08/2023 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |