propoxur (Ref: OMS 33) ** arprocarb ** PHC ** propotox ** ENT 25671 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
Further data may be found in the PPDB

GENERAL INFORMATION

Description: A insecticide and acaricide active against a wide range of pests especially fleas on both domestic and farm animals

Introduction: 1959

Examples of species treated: Domestic animals including cats & dogs, agricultural livestock

General status:

Veterinary substance type	Insecticide, Acaricide
Substance group	Carbamate
Substance origin	Synthetic
Mode of action	Non-systemic with contact and stomach action. Acetylcholinesterase (AChE) inhibitor.
Molecular targets	-
CAS RN	114-26-1
EC number	204-043-8
CIPAC number	80
US EPA chemical code	047802
ATCvet Code	QP53AE02
Therapeutic Class	Antiparasitic products, insecticides & repellents: Ecoparasiticides, insecticides & repellents
Controlled Drug?	No
Regulation 37/2010 MRL Classification	No data
Chemical formula	C11H15NO3
SMILES	O=C(Oc1ccccc1OC(C)C)NC
International Chemical Identifier (InChI)	InChI=1/C11H15NO3/c1-8(2)14-9-6-4-5-7-10(9)15-11(13)12-3/h4-8H,1-3H3,(H,12,13)
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	209.24
IUPAC Name	2-isopropoxyphenyl methylcarbamate
CAS Name	2-(1-methylethoxy)phenyl methylcarbamate
Other status information	Marine Pollutant
Physical state	White crystalline solid
Related substances & organisms	-

Formulations:

Property	Product	Manufacturer	Authorisation Route	UK Legal Class
Example products using this active	Beaphar Flea Spray	Beaphar (UK) Ltd	UK National authorisation (IC)	Authorised veterinary medicine for general sale (AVM - GSL)
	Bolfo 0.25% Flea Spray	Bayer plc	UK National authorisation	Authorised veterinary medicine for general sale (AVM - GSL)
Formulation and application details	Usually supplied as a solution for spary application.

ENVIRONMENTAL FATE

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		1800	H4	High
Solubility - In organic solvents at 20oC (mg l-1)		200000	L3 - Isopropanol	-
		94000	L3 - Toluene	-
		1300	L3 - Hexane	-
Melting Point (oC)		90	E3	-
Boiling Point (oC)		Decomposes on distillation	E3	-
Degradation point (oC)		-	-	-
Flashpoint (oC)		-	-	-
Octanol-water partition coefficient at pH 7, 20oC	P	1.38 X 1000	Calculated	-
	Log P	0.14	G4	Low
Bulk density (g ml-1)/Specific gravity		1.18	L3	-
Dissociation constant (pKa) at 25oC		-	-	-
		Note:
Vapour pressure at 25oC (mPa)		1.3	E3	Volatile
Henry's law constant at 25oC (Pa m3 mol-1)		1.50 X 10-04	E3	Non-volatile
Henry's law constant at 20oC (dimensionless)		6.20 X 10-08	Calculated	Non-volatile
GUS leaching potential index		4.79	Calculated	High leachability
Maximum UV-vis absorption L mol-1 cm-1		-	-	-
Surface tension (mN m-1)		-	-	-
Refractive Index		-	-	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	79	K4	Moderately persistent
	DT50 (lab at 20oC)	30	Q2	Moderately persistent
	DT50 (field)	28	L3	Non-persistent
	DT90 (lab at 20oC)	-	-	-
	DT90 (field)	-	-	-
	Note	Best available data
Manure DT50 (days)		-	-	-
Aqueous photolysis DT50 (days) at pH 7	Value	0.01	K4	Fast
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	180	K3	Persistent
	Note	-
Water-Sediment DT50 (days)		2	K4	Fast
Water phase only DT50 (days)		-	-	-

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	G3	Mobile
	Koc	30
	Notes and range	-
Freundlich	Kf	-	-	-
	Kfoc	-
	1/n	-
	Notes and range	-
pH sensitivity		-

Other known metabolites:

Metabolite name and reference	Aliases	Formation Medium / Rate	Estimated Maximum Occurrence Fraction	Metabolising Enzymes
2-(1-methylethoxy)phenol	-	Soil (Photolysis)	-	-
dimethyl propoxus	-	Plant	0.27-0.36	-

ECOTOXICOLOGY

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF	75	Q2 Estimated	Low potential
	CT50 (days)	Not available		-
Bioaccumulation potential		-	Calculated	Low
Mammals - Acute oral LD50 (mg kg-1)		~ 50	L3 Rat	High
Mammals - Short term dietary NOEL	(mg kg-1)	-	L2 Rat, 2 year	-
	(ppm diet)	200		-
Birds - Acute LD50 (mg kg-1)		25.9	G4 Colinus virginianus	High
Birds - Short term dietary (LC50/LD50)		-	-	-
Fish - Acute 96 hour LC50 (mg l-1)		6.2	E3 Lepomis macrochirus	Moderate
Fish - Chronic 21 day NOEC (mg l-1)		-	-	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		0.15	E3 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		-	-	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		38.1	F3 Chironomus riparius, 1 day	Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)		-	-	-
Algae - Chronic 96 hour NOEC, growth (mg l-1)		-	-	-
Honeybees - Acute 48 hour LD50 (µg bee-1)		1.35	F4	Moderate
Earthworms - Acute 14 day LC50 (mg kg-1)		-	-	-
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		-	-	-
Other soil macro-organisms - e.g. Collembola	LR50product ha EC50product ha NOECproduct ha % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	Harmful	HarmfulAA2 Chrysoperla carnea	Harmful
	% Effect	-	-	-
Other arthropod (2)	LR50 g ha-1	-	-	-
	% Effect	-	-	-
Soil micro-organisms		-	-	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Mammals - Acute oral LD50 (mg kg-1)		~ 50	L3 Rat	High
Mammals - Dermal LD50 (mg kg-1 body weight)		> 5000	L3 Rat	-
Mammals - Inhalation LC50 (mg l-1)		> 0.50	E3 Rat	-
Other Mammal toxicity endpoints		Intraperitoneal LD50 = 30 mg kg-1	V3 Rat	-
		Intramuscular LD50 = 53 mg kg-1	V3 Rat	-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.02	JMPR 1989	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		-	-	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		-	-	-
Dermal penetration studies (%)		-	-	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		[TLV TWA (USA): 0.5 mg/m3], [LTEL (UK): 0.5 mg/m3]	L3	-
Exposure Routes	Public	-
	Occupational	-
Elimination route and rate		Absorbed through skin but in humans it is emininated, as its major metabolite 2-isopropoxyphenol (IPP), via urine within 24 hr of application	R3	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Acetyl cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
		-				-
General human health issues		[Toxic]

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		[No information available]
EC Risk Classification		[T - Toxic: R25], [N - Dangerous for the environment: R50, R53]
EC Safety Classification		S2, S37, S45, S60, S61
WHO Classification		II	-	Moderately hazardous
US EPA Classification (formulation)		II	-	Warning - Moderately toxic
UN Number		2757
Waste disposal & packaging		-

TRANSLATIONS