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dinotefuran (Ref: MTI 446)
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GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for dinotefuran

Description: A neonicotinoid insecticide used to control a wide range of sucking pests

Example pests controlled: Whiteflies; Mealybugs; Thrips; Plant hoppers

Example applications: Vegetables; Fruit; Turf; Rice crops

Efficacy & activity: -

Availability status: Unknown

Introduction & key dates: 1998, first reported; 2002, first registered Japan; 2004, first registered USA

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) Not applicable
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide
Substance group Neonicotinoid
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Systemic, with contact and stomach action, effects insects nervous system. Nicotinic Acetylcholine receptor agonist /antagonist.
CAS RN 165252-70-0
EC number -
CIPAC number 749
US EPA chemical code 044312
PubChem CID 197701
Isomerism A chiral molecule. Commercial products tend to be isomeric mixtures containing a significant proportion of non-active isomers as well as various impurities.
Chemical formula C7H14N4O3
Canonical SMILES CN=C(NCC1CCOC1)N[N+](=O)[O-]
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) YKBZOVFACRVRJN-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C7H14N4O3/c1-8-7(10-11(12)13)9-4-6-2-3-14-5-6/h6H,2-5H2,1H3,(H2,8,9,10)/f/h8-9H
Structure diagram/image available? Yes
Molecular mass (g mol-1) 202.21
PIN (Preferred Identification Name) rac-(E)-N-methyl-N?-nitro-N'-[(3R)-oxolan-3-ylmethyl]guanidine
IUPAC name (EZ)-(RS)-1-methyl-2-nitro-3-(tetrahydro-3-furylmethyl)guanidine
CAS name N-methyl-N'-nitro-N''-((tetrahydro-3-furanyl)methyl)guanidine
Other status information PAN Listed as Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 4A
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Leptinotarsa decemlineata
Physical state White crystalline solid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically -
Example products using this active
  • MTI-446
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details -


ENVIRONMENTAL FATE

for dinotefuran

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 39830 F3 High
Solubility - In organic solvents at 20oC (mg l-1) 0.009 L3 - Hexane -
0.011 L3 - Heptane -
72.0 L3 - Xylene -
150 L3 - Toluene -
Melting point (oC) 107.5 F4 -
Boiling point (oC) Decomposes before boiling CA3 -
Degradation point (oC) 208 L3 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable CA3 -
Octanol-water partition coefficient at pH 7, 20oC P 2.82 X 10-01 Calculated -
Log P -0.549 F4 Low
Bulk density (g ml-1)/Specific gravity 1.42 V3 -
Dissociation constant (pKa) at 25oC 12.6 L3 -
Note: Very weak acid
Vapour pressure at 25oC (mPa) 0.0017 L3 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 8.7 X 10-09 L3 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 4.95 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 3.95 X 10+00 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 82 F3 Moderately persistent
DT50 (lab at 20oC) - - -
DT50 (field) 75 L3 Moderately persistent
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note General literature DT50 range 50-100 days; Other sources: DT50 82 days (US3)
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 6.8 R4 -
Note Published literature RL50 range 1.3-10.0 days, 3 crops grown undercover & in field, various matrices, n=3
Aqueous photolysis DT50 (days) at pH 7 Value 0.2 L3 Fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable L3 -
Note Stable pH 4 to pH 9
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - US3 Mobile
Koc 26
Notes and range US EPA data Kpc range 6 - 45 mL/g
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -


ECOTOXICOLOGY

for dinotefuran

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk Q3 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 2000 F4 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 22.0 L3 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2000 F4 Coturnix japonica Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) > 100.0 F4 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 968.3 P4 Daphnia magna Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 0.79 F4 Mysidopsis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) > 110 F4 Lemna gibba Low
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 100.0 F4 Pseudokirchneriella subcapitata Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 0.023 F4 High
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 4.9 F4 Eisenia foetida High
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 0.2 F3 28 day Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 77.2 F4 Aphidius rhopalosiphi -
% Effect - - -
Other arthropod (2) LR50 g ha-1 30.1 F4 Typhlodromus pyri -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for dinotefuran

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 2000 F4 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 L3 Rat -
Mammals - Inhalation LC50 (mg l-1) 4.09 L3 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.22 L3, Japan -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

General human health issues No further information available

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Powder material may form explosive dust-air mixture
CLP classification 2013 Health: H302, H319
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R22
Xi - Irritant: R36
N - Dangerous for the environment: R53, R56, R57
EC Safety Classification Click here to view information omn the EU safety phrases S61
WHO Classification NL - Not listed
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for dinotefuran

Language Name
English dinotefuran
French -
German -
Danish -
Italian -
Spanish dinotefuran
Greek -
Slovenian -
Polish dinotefuran
Swedish -
Hungarian -
Dutch -

Record last updated: Friday 25 May 2018
Contact: aeru@herts.ac.uk
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